Assassin's Creed/Memory Block Two

Maysaf
At the start of Memory Block Two, there will be a cutscene followed by you being stripped of all of your weapons. You will be given a target to investigate. This basically amounts to a tutorial level in which you will practice the techniques of investigation used in all of your later missions.
 * Objective: Find the Traitor

To begin, head down to the market at the bottom of the hill, toward the Eavesdropping waypoint on your minimap. If you are unsure of your target, use Eagle Vision to locate them. When you have located your target, sit on a nearby bench, lock on and press the head button to listen in. When you are finished, head toward the Pickpocket waypoint on your minimap.

To initiate the Pickpocket, lock on to your target and follow them in Low Profile mode. When you are close enough, "pick pocket" will appear as one of your action selections. Press and hold it while following your target to grab the goods. Make sure that your target does not stop walking while you are reaching for their purse, or they will notice you. Once you have your prize, move to the Interrogation waypoint on your minimap, near the middle of Maysaf village. Your target is the man giving a speech.

Once you locate your target, lock onto him to hear his speech. When it concludes, follow him to the shady area and then beat him senseless. After you land a few punches, he will beg you to stop and then he will confess. For future interrogations, you don't necessarily need to wait until you are in an alcove or under a tree to pummel your target, just be sure that the guards don't see you.

Return to Mualim for a cutscene and a new leg of your mission. You will be given some weapons and your first assassination assignment in the Poor District of Damascus. Head down to the bottom of the hill and out the front gate of Maysaf village. Jump on one of the horses here by walking up to it, and head toward the blinking Kingdom waypoint on your minimap. At the end of the trail, you will enter the Kingdom, essentially the open area between cities.

The Kingdom
Once you are in the Kingdom, your first task is to climb the first of many Reach High points in the game. It is the tower in front of you. Ride up to the tower, dismount your horse and climb up. When you reach the top, press the head button to synchronize. This will reveal some of the map, including hiding spots. Within cities, it will reveal the location of nearby Investigations and Side Quests. Perform a leap of faith off of the plank overhanging the side of the tower and land in the hay below. Grab your horse and head off toward Damascus. Be on the lookout for guards. Now that you are in hostile territory, you performing high profile actions or approaching guards too closely while not blended will cause them to attack. At this point, it is your option to activate all of the remaining Reach High points in the Kingdom as well as look for King Richard flags in the area. Otherwise, head toward the blinking Damascus waypoint on your minimap, avoiding (or killing) soldiers on your way.
 * Objective: Head to Damascus

Damascus: Poor District
Missions Available
 * Investigations: 6
 * Reach High Points: 9
 * Citizen Saves: 12

Investigate Tamir
Ride up to the front gate of Damascus. You'll notice that guards aren't as aggressive here as they were in the Kingdom, but they will still attack you if provoked. When you reach the area before the gate, you will be informed of a citizen that needs saving. Dismount and lock-on to the guard that is harassing the citizen, draw your sword and attack. When the guards are all dead, lock on to the citizen to receive your thanks. In the future, you will need to be anonymous to perform this action, so if you draw a crowd of wandering guards during your attack, you will need to finish them off or blend before talking to the citizen again. Saving citizens is optional, but it provides you with either Vigilantes to slow down guards or Scholars with which to blend in the area where the citizen was saved. Save all of the citizens in a district to increase your sync bar. In this case, the citizen makes a group of Scholars available. Blend with them if you wish to enter the city without provoking the guards. Unblend when you have passed them.

Once you are inside the city, make your way to the Reach High point on your map. At this point a formerly blurred part of the map, the locations of other Reach High Points, the location of the Assassin's Bureau and a few missions will be visible on your map. In order to progress to Tamir's assassination, you only need to perform two of the Investigation missions before returning to the Assassin's Bureau. All other missions are optional, but will contribute to extending your sync bar. For the completionist, this translates to the same pattern for all cities to follow: Starting at the Assassin's Bureau, scale all Reach High points in the district until you reach the one farthest from the Bureau. This will mark the location of all available Investigations and citizens on your map. Then work your way back toward the Bureau, completing missions marked on your map along the way. Enter the Bureau and receive your assassination orders. This will guarantee that you complete each assassination with a full DNA sync.

If you followed the above strategy, you should be roughly in the Northern part of the district when you finish scaling Reach High points. Citizen saves all follow the same procedure as described above, so it is not necessary to describe each one in detail. Investigations can be tricky, however. Starting from the Northern part of the district, you can hit all missions in a clockwise sweep.

Locate two men having a conversation in an alley here. If you are unsure, use eagle vision to pick your targets out. Lock on from a safe distance to listen in. When the conversation is over, follow your target. Stay behind him, and quickly blend if he stops. Avoid bumping citizens, especially those carrying anything. When you have successfully picked, move on to the next mission.
 * Objective: Pickpocket - North

Locate two men having a conversation near the well in this area. When the conversation terminates, follow your target and pick his pocket.
 * Objective: Pickpocket - Northeast

Locate the two men having a conversation in this area and then sit on a bench nearby. Lock on and press the head button to listen in.
 * Objective: Eavesdropping - East

Locate the two men having a conversation in this area and then sit on a bench nearby. Lock on and press the head button to listen in.
 * Objective: Eavesdropping - South

Locate the two men having a conversation in this area and then sit on a bench nearby. Lock on and press the head button to listen in.
 * Objective: Eavesdropping - West

Lock on to the man speaking on a nearby platform in this area. When his speech concludes, follow him to a nearby alley and pound on him until he talks. Return to the Assassin's Bureau to relate the results of your investigation and receive your assassination orders.
 * Objective: Interrogation - West

When the bureau chief places the feather on the desk, pick it up to accept your orders. Your memory will fast forward. When you awake, the location of your target will be marked on your map.

Assassinate Tamir
Climb out of the Assassin's Bureau and onto the rooftop. The fastest way to get to Tamir is by free running along the rooftops in the direction of the assassination target waypoint on your minimap. When you reach the target area, blend and approach to watch the cutscene. Afterward, follow Tamir while blended and avoid the beggars. When Tamir stops at a nearby table, creep up to him and stab him with your hidden blade. Watch the post-assassination cutscene, and keep your fingers ready to catch any glitches. When the scene ends, the alert bell will be sent up and the guards will attack you on sight. Break their line of sight and get to a rooftop, quickly. If necessary, kill any guards that follow you up and then hide in a rooftop garden until you are anonymous again. Make your way back to the Bureau along the rooftops. Enter the Bureau and receive your debriefing. Afterwards you will be told to return to al Mualim for new orders.

Epilogue
When you awake, talk to Lucy a few times to obtain some information about your situation. Afterwards, walk up to the computer terminal attached to the Animus to read Lucy's email. When you are finished, head back to your room to sleep.