The Return of Ishtar/Holy of Holies


 * This is the fourth room in the game to be divided into two sections. Ki and Gil will enter it through either the door at the left of the left section (if they came from The Staircase), or the one at the right of it (if they came from Chantry) - which contains no enemies at all (unless Will O' Wisps appear).
 * The key at the bottom of the left section opens that door at the top of the left section (there are no keys for the aforementioned doors at the left and right of the left section). The door at the top of the left section leads to the right section (Room Pass: still S3Y), and because Ki and Gil are required to go through it, they will re-enter through the door at the top of the right section, which contains fifteen Orange Snakes (which take seventy-two hits to kill). That Treasure Chest in the wall's hole at the bottom-right of the right section will have no noticeable effect on Ki after she has used the Blue Crystal Rod spell on it, and the fifteen Orange Snakes might make it difficult to even reach. The key at the top-centre-left of the right section opens the door at the bottom-left of the right section, the key at top-centre-right of the right section opens that door at the bottom-right of the right section, and the key at the bottom of the right section leads back to the left section (Room Pass: still S3Y). This makes it the first room in the game from which it is physically impossible to escape.