Grand Theft Auto: San Andreas/Yay Ka-Boom-Boom

Note: After completing this mission Big Smoke's Cash and Yay Courier missions will no longer be available as you just have destroyed the yay supply.

After the cutscene, go get the car from the bomb shop, then drive it to the crack lab. Take out the guards on the outside to open the main gate. It might be worth getting out of the car to take out the remaining guards, since, if they destroy the car, you fail the mission. Once it's clear, park the car near the spot indicated, start the bomb timer, and run away. Don't bother shooting the guards on the way out, they'll all get killed in the blast anyway. When you get out, BOOM! Pick off any remaining guards, and head for the main gate. Unfortunately, it shuts just before you can get to it. Shoot the guys by the car, then take out any other guards, then use the ramp to get out. Now drive back to the garage to complete the mission, and that's it for San Fierro!

After completion of this mission, the courier missions given by Cesar Vilapando are no longer available, after all, you did blow up the drug plant.

Tips

 * After blowing up the crack lab, if you head back into the charred remains there is a full health pickup available.
 * You need to be careful how you hit the ramp, as if you aren't properly aligned you will smash into a crate instead of landing on one. It's probably worth walking up to the top of the ramp beforehand so you can see where you need to aim for.
 * I managed to total the escape car by landing it upside down. However, a new one spawned next to the lab. I assume that the supply of spare cars is limitless, so there's no risk of being trapped inside and having to kill yourself to get out.
 * If you climb the boxes and jump the fence you can skip the whole car jumping incident...

Rewards

 * Cash: $25,000
 * Respect: +60
 * Tierra Robada/Bone County and Las Venturas open
 * Safehouses in Tierra Robada/Bone County available for purchase