Fallout 3/Blood Ties

In Megaton, Lucy West wants to deliver a letter to her family in Arefu, and asks you to deliver it for her.

When you arrive in Arefu, you find that the village was attacked by a group known as The Family. On first glance, it appears that they were involved in the death of the West family. After reporting to Evan King, he gives three possible locations they may be - either the Moonbeam Outdoor Cinema, Hamelton's Hideaway, or Northwest Seneca Station.

The cinema is vacant, and the Hideaway is a home to raiders (and a locked door which cannot be picked). The northwest seneca station doesn't contain a family, but a friendly ghoul (looking for sugar bombs) gives the exact location of the family: Meresti Trainyard.

The Meresti Trainyard has plenty of traps to keep out animals and hostiles; but once you get past the traps, the guard in front will let you pass either through great talking skills or by a bribe.

When you enter the family's common room, look for Vance, the leader of the group. He will introduce you to the family and give you the password to the public terminal on the first floor; this will tell you the nature of the family and how they work - return to Vance to tell them about your opinion.

To reach Ian West, you may need to have a high speech score to convince one of the family members to give you the password. If that fails, a high strength can be used on one of the members to get the password.

When you reach Ian West, you can give him the letter or try to convince him to remain with the family. After that, return to Vance to let him know about Ian's decision. (Vance may give you a schematic for a Shishkebab at this point.)

Concerning Arfeu, you have a few options available; additional options can be made through Speech, Medical skill or Intelligence. From there, you can setup a bloodpack exchange program between Arfeu and the family - after telling Evan King about this and returning to Vance, you can learn the Hemotophage Perk, which boosts the amount of health given from bloodpacks.