Grand Theft Auto: San Andreas/Vigilante

Get in the vehicle, drive to a suitable location, and hit R3 to start the mission. Criminals will appear as red blips on your map and radar. Go destroy the cars and kill the perps.

As in the Firefighter mission, the number of targets increases by one each level. When you have more than four people you will have more than one vehicle. 1-4 people will be in the same vehicle, 5-8 will be divided into two vehicles and 9-12 into three. Although you can continue beyond level 12, more than 12 people will not appear in any level.

Tips
The Police vehicle that you pick can play a major role. The police motorcycle (HVP-1000) allows for faster travel and steering than the cruiser, and allows the player to fire a micro SMG forwards while driving rather than doing a drive-by.

Recruiting up to 3 gang members to accompany you on the mission may help. Every level adds one person to be eliminated, and Start the mission in a small town (e.g., Fort Carson) so there aren't as many innocent bystanders getting in the way.

Using the Hunter Helicopter
If you have finished the flight school with all gold awards, "The Hunter" AKA "The Ultimate Vehicle" (an Apache helicopter) will appear at your desert airbase. The hunter allows superfast travel, plus it can fire rockets and minigun at enemies, allowing a quick elimination. Eliminating enemies using the hunter's machine gun will also not attract any police attention. It is relatively easy to reach any vigilante mission with this helicopter.

The Hunter gunship can also be obtained by entering the "Heli Hell" race tournament at Las Venturas Airport. You'll start in Los Santos; just fly directly to the Verdant Meadows airstrip in L.V. and store it in the hangar there, or fly it to your race-trigger point at LVA, land, jump out, wait for the timeout, then exit the race. That's faster than storing, since you already have it sitting next to you for the Vigilante mission.

Using the Rhino tank
Another possibility is getting a Rhino tank. Find a ledge in the desert near a street and get all stars by killing policemen, when the military gets called steal a tank and get it to the airfield garage and save. It is also possible to steal a Rhino from a hanger in the Restricted Area by smashing a destructable fence on the North-East side, or by using the jetpack. While this does earn you 5 stars, your airfield is very near, and so it is relatively easy to leave the tank in the garage and save head to a Pay-n-Spray on a bike.

Note that the aircraft "garage" is not the same as the auto garage near the AC tower, nor one of the hangars, but the large building in the southeast corner of the airfield. Its door is on the north face (facing the airstrip). It's large enough to hold a vehicle as tall as the Rhino.

You will not be able to enter the Rhino if it's parked in an auto garage. You will have to (slowly) push it out.

The Rhino is nearly (but not completely) indestructable and it can fire its main gun. It's slow but once you reach the target the kills are quick; you can fire the gun or just run them over causing the cars to blow up too quickly for the passengers to get out. So you will have plenty of time.

Glitch
There is a glitch in the game which makes vigilante missions extremely easy to complete: simply get a police car (general consensus is that it MUST be a police CAR, but some people report a police bike working) and activate the mission. Next, go into a fast food restaurant or bar and walk around until the message comes up that the criminals have been terminated. Go back into your police car to start the next level and then repeat the process. This also sometimes works when visiting a clothing store or a 24/7.

I've found that doing this glitch in Los Santos doesn't work well, because the baddies are often spawned in rural areas which the cops don't get to quickly enough.

The trick is to wait until you're in San Fiero, and start the glitch near the north end of the city, just south of the bridge, like at the Pizza joint there. All the baddies spawn downtown, and the cops get to them rather quickly. Yeay.

Rewards
Finish level 12 to increase maximum armor to 150. There are cash rewards as well. (Some have written that this does not work with PC version).