Resident Evil 5/Chapter 2-3

This chapter shouldn't take too long. If you're playing on Veteran or Professional, however, it should prove to be quite a challenge. No matter how much you love your guns or how hard you worked to obtain them, you won't be able to use them. Here you're stuck with the turrets on the vehicle. Chris will have the machine gun on top and Sheva will have the one on bottom. The upside is that these guns actually have infinite ammo. As great as that seems, unfortunately, there's a downside. The guns can overheat if you rapid-fire non-stop, so pay attention to the meter at the corner of the screen.

Get an achievement/trophy by having Chris shoot the driver of one of the trucks. This will stop the whole truck and the shooters won't be able to come after you. The motorcycle Majini, needless to say, will be easiest to handle. Press a button when told if you need to grab onto the truck (the road is quite bumpy). At one point, a truck and a large group of Majini will be trying to stop your ride. Shoot them all down by aiming for the oil drums (if you didn't get the achievement/trophy "Baptism by Fire", now would be the time to get it). Eventually, the truck will explode and you'll be able to pass. Fight a few more enemies and then the car will make a jump.

Following a cutscene, you'll be fighting a boss. It shouldn't be too much of a problem to defeat on Amateur and Normal. Try to ignore the shooters on the right as much as possible (don't ignore the Molotov Majini on the left though) and perform the necessary button sequences. Keep shooting (remember to watch for overheating) at the things that come out of its chest and shoulders (first a group of two, then always four). Eventually, after shooting the large thing that comes out of its back at least two times, the boss will be defeated and the chapter will end.