No More Heroes 2: Desperate Struggle

No More Heroes: Desperate Struggle (ノーモア★ヒーローズ デスパレート ストラグル) is an action video game currently in development for the Wii video game system. It is being directed by Suda51, developed by Grasshopper Manufacture, published by XSEED Games and Rising Star Games, and has a tentative release date of January 2010 in North America, and February or March 2010 in Europe. A Japanese release date has yet to be determined, as a press release by Marvelous Interactive, who were responsible for publishing No More Heroes in Japan, confirms only that XSEED will be handling the publishing of Desperate Struggle in North America, and that plans for release in Japan are currently undecided.

Travis Touchdown, the series protagonist, is said to have withdrawn from the ranks of the UAA for three years. During those three years, Travis has fallen to 51st place, and Santa Destroy has been taken over and renovated by the "Pizza Butt" corporation, who in the first game were looking to open restaurants in the town.

Sylvia Christel, the "agent" who convinced Travis to join the UAA, has returned to invite him back into the ranks once more. Motivated not only by Sylvia, Travis is also fighting to avenge the death of someone close to him. Travis' friend Bishop Shidux is shown in a scene in the reveal trailer where various hitmen hold up his store, brandishing firearms.

The E3 trailer showcased at least one boss fight against a man, Nathan Copeland, brandishing a morphing beatbox, as well as Kimmy, a teenage schoolgirl and Travis admirer with a double-edged katana who became an assassin to meet him.