Diablo II/Radament's Lair

If you talk to Jerhyn, Lord of Lut Gholein, upon arrival then you'll know that Atma, the tavernkeeper, has an important mission for you. You'll find her tavern on the other side of town, to the northeast. Talk to her to activate the first quest.

Before following her directions and leaving Lut Gholein, it's at least worth it to talk to Meshif as well:

Sewers Level 1
Although it's true that a sewer entrance is through the trap door just up the street, at the feet of the mercenary captain Greiz in the north corner of town, the stair down to the second level is actually more likely to be closer to the other entrance mentioned by Meshif. Go to the south corner of town and you'll find stairs down to it by the docks; if you insist on going through the trap door, once down there head south rather than west.

The first level is randomly populated by three of the following four monster types:, s, s (Mummies who emit a cloud of poison upon death) and s.

Sewers Level 2
The second level is similarly populated to the first. There's also a waypoint, the most direct route to which is normally achieved by traveling to the left upon entry, and continuing to do so for the stair down to the third level.

Sewers Level 3
The final level is randomly populated by three of the following four monsters:, fiery s, s and es (Saber Cats). Continue traveling left upon entry for what is likely to be the most direct route to Radament's lair. Your quest log will alert you once he's nearby, activating this quest if you haven't already done so by talking to Atma.

If you return to the surface before completing this quest:

Unfortunately, Lysander doesn't actually trade throwing potions...

Radament


We live again!

Once you've been alerted to Radament's presence, stop. Aside from any randomly generated monsters in the area, there can also be both electric and poisonous s, fiery and icy s, s, and Radament himself has minions: he can raise any undead you kill, so unless you have a reliable means of using or destroying corpses, or area of effect damage, it may be prudent to retreat and try to draw as many as possible out of his awareness range so he cannot raise them.

When you're ready, charge forward to kill him: he can fire unholy bolts at range, and attack you with a poisoned claw or breathe poison over you in melee range. This can be tough if you aren't able to prevent him from raising undead, or distract them, but once you've killed him holy bolts radiate from his corpse to kill any remaining undead in the area.

Radament himself drops a Book of Skill: right click to learn skill of your choice (a skill point!). He was also guarding a chest, which contains a Horadric Scroll if you don't already have a ../Horadric Cube/, activating the second quest if you haven't already done so.

If you talk to anyone but Atma upon your return to the surface:

Talk to Atma, and she'll confirm that vendor prices in Lut Gholein have been reduced (by 10%):

You can now talk to Jerhyn (again) on the steps of the palace on the other side of town, in its western corner, to activate the sixth and final quest for this Act, but there's no point in doing so before you have a Horadric Staff...