Kid Icarus: Uprising/Medusa's Final Battle

In this chapter, you are equipped with the Three Sacred Treasures. Essentially, this means your shots are powerful and have great homing, and you can fly for however long as is necessary. In future playthroughs, it is possible to use normal equipment, but the treasures are required the first time around.

Air Section
You'll quickly be attacked by a bunch of enemies, but with the Three Sacred Treasures, they should not be too much of a problem. More concerning are the Trailtails, which create barriers as they move along. Kill the Trailtails to destroy their respective barriers. Immediately afterwards, you'll have to deal with Shootflies, which will swarm you if you used ranged attacks. However, you can still use melee attacks and dodging to deal with the other enemies, so don't let yourself be an easy target. Alternatively, feel free to open fire, so long as you make the Shootflies priority targets.

After the Shootflies, you'll enter a narrow tunnel and collect some Recovery Orbs. Along the way, you'll meet your old foes, the deadly Ornes. The good news is, the Three Sacred Treasures allow you to kill them, so open fire! Just remember that touching them still kills in one hit.

Once you enter the Underworld, you'll be swarmed by enemies. These will include Boogities. Unfortunately, the Arrows still aren't effective against their shields, meaning you'll have to fight them carefully. The good news is, Dark Pit will show up and damage the enemies. He's on your side now, and will take out an enemy or two. How nice. Soon, you'll see Medusa. She'll sick a miniboss on you: The Underworld Guardian.

The Underworld Guardian is essentially composed of a bunch of turrets atop a main body. Take out the turrets first before focusing your fire on its head. Occasionally, it will disappear, create a line across the screen, and attack along the line. Dodge those attacks by simply avoiding the area. Blast through the barriers it makes too, or they will corner you and do damage. Soon enough, Dark Pit will jump in and finish the Guardian off.

Ground Section
This Ground Section is composed of four separate sections, each of which is connected to a door. The first three can be done in any order, and end with a boss from earlier in the game. All three bosses should be easier by now, thanks to your experience and the power of the Three Sacred Treasures. Feel free to tackle them in any order you want, and heal at the hot spring after every part.

Twinbellows
Just shoot whatever moves and keep on going. The only real threat should be the Reaper, but so long as you attack it from a distance and keep away, you should be fine. The real threat is the Clubberskull that appears in a narrow corridor. Shoot it and run simultaneously! Above all else, keep your distance, especially since your bow is primarily a ranged weapon. Use the nearby Lightning of Judgment to deal extra damage before you get cornered.

Up ahead, grab the treasure chest on the staircase to the right before going up. In the plaza halfway up, you'll see an Exo Tank. Drive it the rest of the way up the stairs and destroy every enemy with it. Even if you have trouble running them over or shooting them, it's safer to face enemies in the tank than out of it, especially the Clubberskull. When you're done, grab the Drink and prepare to face Twinbellows.

Honestly, Twinbellows should be a walk in the park, especially this second time around. Just strafe and dodge its attacks

Hewdraw
Advance through the few token enemies until you find a new vehicle: the Aether Ring. Use it to quickly strafe enemies by shooting and running circles around them. Using the same strategy as you did against Twinbellows works well here for the mass you have to fight.

Head into the well, and you'