Assassin's Creed/Memory Block Three

Acre: Poor District
Your target is the Grand Master of the Knights Hospital – a man who likes to experiment on kidnapped men from Jerusalem. He hides himself away inside the Order's hospital, so you'll need to investigate the best way to infiltrate his fortress and take him out.
 * Objective: Assassinate Garnier de Naplouse

Investigations

 * 1) Eavesdropping
 * 2) Informant
 * 3) Informant
 * 4) Interrogation
 * 5) Pickpocket
 * 6) Pickpocket

Assassination
Garnier is in the Hospitalier Fortress, which is a building with guards at the entrance and tons of sick patients and lunatics inside, as well as more guards. To get into the hospital, blend in with the nearby Scholars, who will head inside. Garnier walks around from section to section, checking in on his patients. Guards are stationed between each section, so you'll have to stick with the Scholars to move around the building. They will continue to circle the building and Garnier will continue to circle the building, both indefinitely. There are three ways to approach this kill. One way is to just go for Garnier as soon as you see him, regardless of what's going on. This results in a pitched battle against the guards and Garnier himself, who is tougher and faster than his underlings.

For a more assassin-like take down, you'll want to smoothly lock on, go into high profile and then attack with your hidden blade, all while being very close to your target. The two ways to do this are by circling around forever, waiting for the perfect alignment of the Scholars and Garnier before attacking, and the other is to break from the Scholars and wait for Garnier to come to you. The danger to the latter course of action is that being jostled by the roving lunatics will break your cover. It's a little safer to have some patients and use the Scholars to blend until you're ready, but if you can find a calm place to wait, it will likely be much faster.

After taking out Garnier, run out of the hospital and lose your pursuers in the city. When you've regained your clean status indicator, make your way to the Bureau to report in to the rafiq. After showing your bloody feather you'll have the option to be transported back to Al Mualim in Masyaf. You'll receive the ability to carry five throwing knives and tackle people out of your way when you're running so you don't lose your balance. After training in the courtyard on your new weapon, head to Jerusalem.

Jerusalem
Talal is a slaver who kidnaps the helpless citizens of his city and then sells them to the highest bidder. This was the source of Garnier's test subjects in Acre. Talal has a loyal following of guards, and he's not a traditional fighter, preferring to leave his minions behind to occupy you while he puts his mastery of the bow to use.
 * Objective: Assassinate Talal

Investigations

 * 1) Eavesdropping
 * 2) Informant
 * 3) Informant
 * 4) Interrogation
 * 5) Pickpocket
 * 6) Pickpocket

Assassination
You'll strike while Talal is inspecting his slaves in his warehouse within the Barbican to the north. The area has guards at the entrance, so use Scholars to get inside. Once you're up the steps, go ahead and unblend and continue on to Talal's warehouse, as the Scholars don't go in very far. Follow your target icon to the entrance of the building and go inside.

Even though he's set a trap for you, this is a much easier assassination than it would seem – just ignore everyone but your target. Talal is an archer and likes to strike from a distance, so he will just run away from you as long as you're chasing him. When you start out, don't bother fighting anyone, just head up the ladder on the side of the room and follow Talal outside. All you have to do is chase him down, and if you have your hidden blade equipped, you'll take him out when you're near enough as soon as you attack. When it's done, find a hiding place to get back to safe status, then go back to the Bureau and let Malik know you've completed your mission. He'll tell you to go report back to Al Mualim, but your memory block ends before you can start black to Masyaf.

Epilogue
After leaving the Animus, talk to Lucy a bit to find out a little more about your situation. When you head to your room this time, you'll see that your closet is open. If you search it, you'll find the keycode for your locked bedroom door. This will let you out to explore, although there's not much to do out there.