Golgo 13: Top Secret Episode/Act 13

Although you begin a new act, if you die here you will be returned to the start of the water section of the previous act. You will begin to walk through the Proto-Command Module. Walk to the right and jump over the first laser defense system. Shoot down the next two floating officers for more health if necessary. Use your discretion as you make your way past the remaining obstacles and over to the elevator on the far right. When you reach it, push and you will enter a strange room with a brain in the center.

The brain will actually welcome you. It seems that the body of Smirk is irrelevant, and clones are made from the blueprint of the brain itself. It offers to give you the vaccine, but warns against getting too close. The brain then explains that you have three minutes to kill it or a nuclear missile will explode. The final battle will now begin.

Final Battle
Alongside the brain are a series of tubes from which the clones are generated. Only certain tubes will activate, signified by a blinking red light above them. Fighting the clones is fairly straightforward. You must shoot them while they are far away. This will cause the clone to appear close up. You must shoot it close up to make the body explode. Then the head will fly off. You must shoot the head to kill the clone. The clones fire circular beams at you that do 20 points of damage, but the heads can cause 40 points of damage if allowed to fly close up to you. Killing the heads quickly is key.

However, the clones are not your primary objective. Destroying the cloning tubes is. You must shoot that blinking red light roughly ten times until it explodes. When the lights go out, you must remove any remaining clones before the next part of battle will begin. After destroying the two tubes on either side of the brain, the two tubes on the far right side will light up. Repeat the process of shutting down the tubes by shooting the red lights, and clearing up the clones.

The next tubes to light up will be the three to the far left of the brain. It's important to be quick here because three clones can cause of a lot of damage to Golgo 13 if left unchecked. Take out the red lights and then destroy all three clones. When this occurs, three targets will appear on the opposite side of the room from the brain. They will move back and forth along a track and fire beams at you. These beams will do 20 points of damage if you only catch them sides of them, but they will do 40 points of damage if you take them straight on. Destroy these three moving targets as fast as you can to minimize the amount of damage you take.

Finally, when the three targets are destroyed, return to face the brain. A new stationary target will appear below the brain. Shoot it to cause the brain to elevate in the room. The game will switch to sniper mode, where you will already be locked on to the brain. Press to zoom in, and  to shoot. The brain will be destroyed and you will have won the game. Congratulations.