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| Item | Description | Location |
|---|---|---|
| Amulet Coin | Doubles earnings from Pokémon battles | Underground Goldenrod see Radio Tower |
| Berserk Gene | Boosts Attack but causes confusion | Cerulean, where Mewtwo cave was |
| Black Belt | Increase power of Fighting-type attacks | Lake of Rage on Wednesday |
| Blackglasses | Increases the power of Dark-type attacks | Dark Cave |
| Bright Powder | Lowers the opponents accuracy | Traded (RBY) Legendary |
| Charcoal | Increases the power of Fire-type attacks | Azalea Town |
| Cleanse Tag | Repels wild Pokémon | |
| Dragon Fang | Increases power of Dragon-type attacks | Dragon's Den |
| Dragon Scale | Evolves Seadra during trading | Mt. Mortar |
| Everstone | Prevents a Pokémon from evolving | Bug Catching Contest/ Professor Elm |
| Exp. Share | Gives a Pokémon an extra share of Experience | Mr Pokémon, give him Red scale |
| Focus Band | Prevents a Pokémon from fainting occasionally | |
| Hard Stone | Increase power of Rock-type attacks | Route 36 - From Arthur on Thursday |
| King's Rock | May cause flinching when opponent is hit | Slowpoke Well - Needs Surf and Strength |
| Leftovers | Recovers HP gradually during battle | Caught with Snorlax |
| Light Ball | Doubles Pikachu's Special Attack (An odd electrical orb) | Pikachu may hold whan caught |
| Lucky Punch | Ups ritical hit ratio of Chansey | Chansey may hold when caught |
| Magnet | Increases the power of Electric-type attacks | Sunny - Route 37 on Sunday |
| Mental Herb | Prevents your Pokémon from becoming attracted to an opponent | |
| Metal Coat | Increases the power of Steel-type attacks | S.S. Aqua |
| Metal Powder | Raises Defense of Ditto | Ditto may hold when caught |
| Miracle Seed | Increases the power of Grass-type attacks | Man at Route 32 after beating Gym |
| Mystic Water | Increases the power of Water-type attacks | Cherrygrove city - from fisher on island - needs Surf |
| Nevermeltice | Increases the power of Ice-type attacks | Ice Cave |
| Pink Bow | Powers up normal-type moves | Route 29 (Tuesday) and Radio Tower |
| Poison Barb | Increases power of Poison-type attacks | Feridia on Friday (route 32) |
| Quick Claw | Increases chance of attacking first | National Park |
| Sharp Beak | Increases power of Flying-type attacks | Monica on Monday (route 40) |
| Pink Bow | Increases the power of Normal-type attacks | Radio Tower see Radio Tower, and Route 28 on Tuesday |
| Silver Powder | Increases power of Bug-type attacks | Catch Butterfree |
| Smoke Ball | Escape from wild Pokémon | |
| Soft Sand | Increases the power of Ground-type attacks | Route 34, after surf is learned see Route 34 |
| Soothe Bell | Speeds up the development of a Pokémon's friendship | |
| Spell Tag | Increases the power of Ghost-type attacks | Santos - Blackthorn city on Saturday |
| Twisted Spoon | Increases the power of Psychic-type attacks | Traded (Y) Kadabra |
| White Herb | Cures status conditions |