Town Majini[edit]
These are normal mobs in the first couple chapters that you will encounter throughout the game. They will carry any thing they can use as a weapon from wrenches and metal poles to machetes and flaming bows.
Cephalo[edit]
When Majini are damaged enough, some will mutate to sprout a Plaga tentacle from their necks. The main body gains a higher endurance than it did before. The Plaga can retract to attack at short or long range. Shoot the Plaga tentacle to destroy it.
Kipepeo[edit]
These flying mobs will sprout out of the backs of Majini when the host body receives enough damage. These enemies have a sharp whip-like tail that can attach to you and you must break free.
Adjule[edit]
Infected dogs that turn against you. They will leap and pounce on you to chomp and bite you. If they receive enough damage that isn't completely fatal, their head will split and the Plagas will appear.
Executioner[edit]
The first boss you fight. He wields a makeshift axe made of a guillotine blade with a chain. Shoot him until he goes down. There are some fuel canisters that you can ignite to deals some hefty damage to him. Be careful not to get too close as he can knock you down and use that guillotine blade as it was made for.
Uroboros[edit]
A human, once, but now a failed Las Plagas host. It's constant squirming tentacles allow it to squeeze into tiny spaces. It's weak point is a glowing orb of flesh on it's body. It's major weakness is fire.
Big Man Majini[edit]
These foes are just like wrestlers. They can tank a lot of damage before finally falling. If you knock them back, from say a shotgun, you can walk up to them and melee combo them.
Chainsaw Majini[edit]
A tall Majini with a burlap sack over his face. He can dish out and tank some serious damage. If you get too close, he can use the chainsaw to saw through your neck like a wooden log. When you damage him enough, as a last resort, we might get back up and wildly swing his chainsaw, finish him off until he falls to his knees and collapses.
Motorcycle Majini[edit]
You will encounter these guys in a cutscene and riding the truck. These guys will carry varying weapons from wrenches, glass bottles, and fire bombs to lob at you as you ride the car. Either shoot the motorcycle to explode or shoot them off the bike.
Popokarimu[edit]
A giant bat organism. It's pretty much bulletproof unless you shoot the fleshy red meat underneath it's tail. Using a proximity mine to knock it down to shoot it's red tail flesh. Shooting an RPG into it's head or it's red flesh will instantly deter or kill it.
Ndesu[edit]
Just like it's European counterpart, El Gigante. It will be a walking a bullseye. Just shoot it. Especially, when it tries to stomp on you, throw a giant boulder at you, or when it's Las Plagas tentacles sprout from it's body.
Tribal Majini[edit]
A refined Las Plagas of the Town Majini infects the Ndipaya tribe. They discard their clothes to don loincloths and weapons of war belonging to their ancestors. They have heightened agility and jumping as they can leap to climb tall ledges.
Giant Majini[edit]
These howling giants wield spears and don a giant mask of bone and wooden that prevents any insta-kill headshots. Shooting their exposed legs will make them kneel and you can melee combo them to equal the power of a grenade on them.
Duvalia[edit]
A Majini just like the Cephalo, but it has a tough layer of flesh to protect itself from bullets. You can shoot a loose hanging chunk of flesh at it's leg to make it drop to its knees. It's head will expose it's Plaga parasite, shoot it to kill it. A Flash grenade can instantly kill it once it transforms. It also has a move it can instantly kill you if you get too close by swallowing you.
Irving[edit]
A giant mutation of multiple organisms of crocodiles, fish, and mollusks. It has a glowing chunk of flesh on it's head that, if damaged enough, will cause Irving to dive in the water and use his tentacles to strike you on the gun boat. Eventually, if damaged enough, he will grab onto the rear of the boat and the mouth will open up and Irving will taunt you. Shoot him until the entire host body convulses violently.
Bui Kichwa[edit]
Likely infected tarantulas. These can be killed by using Flash grenades to instantly kill them. If these get too close, they will leap on you and give you a hug, as they start draining your health.
Beta Licker[edit]
These mobs are an advanced form of it's counterpart in Raccoon City. It's poor eyesight is still unfixed, but it's hearing and smelling have been significantly heightened. It will also crawl and cling to walls and ceilings. It can strike you with it's tongue and claws. It can pounce you, and if not freed in time, it will slash you and pierce your heart to kill you. If you can knock it onto it's back with a shotgun, you can run up to it and stab it's exposed heart to instantly kill it.
U-8 Uroboros[edit]
A giant mutation of crustaceans and a spider. Shooting it's leg ligaments to make it fall and shooting/throw grenades into it's gaping mouth. It's carapace will be blown off piece by piece. Sometimes it will release flying insects to distract and attack you. It will slam the platform you're standing on to knock you off balance.
Mkono Uroboros[edit]
It is just like the first boss in the game and shares it's weaknesses. Expose it's fleshy core and fire. Use the flamethrower to kill it or use the Incendiary grenade, along with the Grenade Launcher with Flame Rounds.
Reaper[edit]
A mutated cockroach and grasshopper with the virus. It is completely bulletproof thanks to it's exoskeleton. It also produces a nasty, stunning, mist that prevents seeing it. It will sprout white glowing orbs that are the only way to kill it. They will sprout from it's chest, back, and sides.
Brainwashed Jill Valentine[edit]
Chris' former partner after being injected with superhuman strength, but lost her free will. Chris will have to entreat Jill until she resists the device on her chest. Chris or Sheva will have to restrain her until the other will shoot the device to weaken it and then Jill will have to be thrown to the ground and then Chris will have to tear off the device. Jill will eventually return back to normal once the device is torn off.
Aheri Uroboros[edit]
Excella infected by Wesker and absorbing tons of bodies. Almost bulletproof. Shoot the glowing orbs until they explode and then shoot the giant orb until it also explodes. Use the laser satellite to strike the giant orb. It also throws an infinite source of little versions of itself.
Mini-gun Majini[edit]
This tank wields a minigun. His entire back is protected from bullets by the metal case. Either you can use the environment to protect you by taking cover, using convenient explosives or placing proximity bombs to whittle his health down.
Uroboros Wesker[edit]
As you and Sheva run over a stony bridge and breaks, you will be separated. As Chris, lure Wesker to shoot him in his back with a tiny glowing piece of flesh to weaken him. Then he will switch to attack Sheva. As you run over to a boulder, Sheva will barely hang on, shoot Wesker until Sheva can climb back up. Knock the boulder into the magma and lava for Sheva to meet up with you, before Wesker knocks her into the volcano's pool of molten rock. After you and Sheva meet up, run back to the center arena, for Wesker to attack you both. Wesker will try to strike you with his enlarged Uroboros arms. Run behind him to strike at his exposed flesh. Don't try to get too close, as he may use the tentacles of Uroboros to attack anyone too close to him. This will knock whoever is hit to be pierced by the constant barrage of tentacles. Eventually Wesker's chest will expose another weak spot. Chris must run up to him and restrain him as Sheva must cut her way through. Then Wesker will try to kill Sheva, but Chris must attack Wesker's back and Chris and Sheva will stab Wesker completely through.