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If you're hurting, rest at Frank's.
As Fatima suggests, head back to talk to K'Conrad. You'll get attacked along the way; try out Grumpos' Yammer Bouge skill. It stuns opponents, which is very useful.
Talk to K'Conrad. While you're there, tell Maria where Simon lives, for $50. Now head for the Fountain Spiral. In the gravpath is a NoxGuard who wants photos of five Brebulans. You already have them, so he gives you $500.
From the Spiral, head toward Rowdy's, but turn left into the area that used to be blocked off, and turn right into the tunnel. Talk to Yerocan Worb, who gives you some blueprints.
Now head for the MysTech Museum and talk to the curator, who asks you to photograph the five Anachronox symbols. It seems that you need to leave the museum and come back in before you can tell him you have the photos, for which he gives you $200 and 3 HealGrease Plus. He also wants you to grab the symbol from the Anachronox Tours office.
Head upstairs in the museum (the stairs are by the entrance). As you leave the tunnel, look down over the railing to your left. If the Red Bipidri isn't there now, it will show up soon. Take a picture.
On the path to Zordo's, the guy watching the Bipidri work asks you to photograph 8 Red Bipidri. Talk to him again to get credit for the ones you already have. After you talk to him, hit F8 for the Collectables menu. If you don't have credit for two, one of them must not have counted. Look at the .dat files in your save game directory to see which. Once he gives you credit, you can delete the photos.
Now head back to Rowdy's and give the blueprints to Marina for $200. Mardoman asks you to check up on Yerocan again. Also talk to Valesta; you don't have to give her the bracelet.
Head back to Yerocan, who asks you to photograph any suspicious characters in the Fountain. Head up to the top of the spiral and take a photo of Fazz Burbleman. While you're there, talk to the FlingBot watching the fountain for a laugh. Report back to Yerocan, who gives you an Eluder Band (Block +1). Visit Mardoman again; he asks you to hit up a drug courier in the Platform Area.
Now it's back to the Tenements to find Lucko Coldwolf.
In the Tenements, head to the right and down the stairs until the cutscene starts. Follow Lucko back through the Junkyard, Casinox, Platform and Anachronox Tours areas, and into a bar for another cutscene. As you leave, Fatima tells you to look up a guy in the Fountain Spiral area. But first, let's look around:
Turn right and talk to the guy in black standing over the dead body. It's Detective Rukh, an old friend. He wants you to investigate the dead man's apartment back in Building 5.
Return to Building 5, Level 2, Room 7, and look at the LifeCursor on the counter.
If you want, you can visit Deanamo again, and talk to her with Grumpos. You can either pay her $200 to get healed, or mock her. If you pay her, she'll show up in Ghalla's, but if you go back to Frank's later in the game she's there again, like it never happened. Oops.
Head back to Rukh with the info. He gives you a PAX Flashpak, which teaches him FlashBlind, Boots' Stun skill. Note the guy with the purple PAL-18 unit.
Head up the stairs and into:
Head around back through the Maintenance section, and grab the Anachronox symbol.
Head for the Tours area exit, but just before the signs to other areas, turn right and talk to the NoxGuard. Walk back up the stairs to the other highway view, and take a photo of the red motorcycle. Return to the guard for $75.
Now go to Platform 3, and fight the drug dealer. Head back to Mardoman and the Museum for your rewards (a Pre-owned ShieldCell and $400, respectively). The guy with the sock is wandering around near where Yerocan was standing. If you want, you can visit Zordo's Gun Palace and buy some Wristbands of Whacking for $1200. They increase your damage by about 5%.
OK, time to go visit Eddie. Head for the Junkyard Area, and talk to the Brebulans, who want a symmetrical crystal tree. Enter the Junkyard and save.
You'll be doing a fair amount of fighting in here, so be prepared. Remember to use Yammer to take enemies out of the fight temporarily.
Turn left at the fork and grab the Pre-Owned Shieldcell off of a box. At the second fork, go around to the right and grab the TACO before heading up the ramp. Talk to the doorman, and continue on. Past the TimeMinder, look behind a box on the left for a Vistin ThreeBeam (Boots, Poor, Ranged). Continue on for a cutscene.
When you're done with Eddie, head back to the first fork and go the other way. Look at the crystal trees until you find a symmetrical one, and take it back to the Brebulans for $175.
Head down to the Lower Tenements, and around back to the Doorlord. Make sure you've done everything in the Bricks first, as you won't be back for a little while.