Splicers[edit]
Splicers are humans who have gone insane by using too much ADAM. They are vulnerable to anti-personnel rounds.
Thuggish Splicer[edit]
Thuggish Splicers only have melee weapons such as wrenches.
| Level | Reward |
|---|---|
| 1 | Increased damage |
| 2 | Increased wallet cap - you can carry more cash |
| 3 | Increased damage |
| 4 | Scrounger tonic |
Leadhead Splicer[edit]
Leadhead Splicers carry a gun: either a pistol, machine gun, or shotgun. They can also throw grenades or molotov cocktails.
| Level | Reward |
|---|---|
| 1 | Increased damage |
| 2 | Cameras are slower to activate alarms |
| 3 | Increased damage |
| 4 | Thrifty Hacker tonic |
Brute Splicer[edit]
Brute Splicers are strong and fast. They throw large objects at you or charge in to attack up close.
| Level | Reward |
|---|---|
| 1 | Drill Dash ability |
| 2 | Increased melee damage |
| 3 | Increased damage |
| 4 | Armored Shell 2 tonic |
Spider Splicer[edit]
Spider Splicers can crawl on the ceiling as well as throw hooks. They also often come in close for melee attacks.
| Level | Reward |
|---|---|
| 1 | Increased movement speed |
| 2 | Use Spider Splicer organs as First Aid Kits |
| 3 | Increased movement speed |
| 4 | Fountain of Youth tonic |
Houdini Splicer[edit]
Houdini Splicers use elemental attacks such as fire or ice. They use teleportation to avoid attacks.
| Level | Reward |
|---|---|
| 1 | Increased damage |
| 2 | Houdini Splicer movement is easier to predict |
| 3 | Increased damage |
| 4 | Natural Camouflage tonic |
Security[edit]
Security includes the various cameras, turrets, and bots you will encounter throughout the game. They should usually be hacked instead of destroyed, but are vulnerable to armor-piercing rounds.
| Level | Reward |
|---|---|
| 1 | Increased damage |
| 2 | Find double ammo on destroyed security machines |
| 3 | Increased damage |
| 4 | Deadly Machines tonic |
Big Daddies[edit]
Big Daddies protect Little Sisters. These enemies are vulnerable to armor-piercing rounds. They will not attack until attacked first.
| Level | Reward |
|---|---|
| 1 | Increased damage |
| 2 | Increased drill damage |
| 3 | Increased damage |
| 4 | Arms Race tonic |
Bouncer[edit]
Bouncers use drills for close range attacks.
Rosie[edit]
Rosies use rivet guns as well as proximity mines.
Rumbler[edit]
Rumblers throw out mini-turrets and grenades, but can also charge in for melee attacks.
Big Sister[edit]
Big Sisters are fast and powerful enemies that appear when the last Little Sister from each level has been rescued or harvested. They can use Telekinesis and elemental plasmids to attack. They are vulnerable to armor-piercing rounds.
| Level | Reward |
|---|---|
| 1 | Increased max EVE |
| 2 | Little Sisters restore health after Gathering ADAM |
| 3 | Increased max EVE |
| 4 | Drill Vampire tonic |
Alpha Series[edit]
Alpha Series Big Daddies attack using some of the same weapons as the player. They are vulnerable to armor-piercing rounds.
| Level | Reward |
|---|---|
| 1 | Increased damage |
| 2 | Increased ammo capacity |
| 3 | Increased damage |
| 4 | Elemental Storm tonic |