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Here, I'll list where the item is found, a short description of the item,and what it is used for. This is a good place to go if you're stuck anddon't want to read the walkthrough - this list will tell you which item to use without reading paragraphs or spoilers. It's also in chronological order.
Found: Outside Cafe near Streetlight
Description: Regular newspaper with horse race words on back
Used: To get the construction worker to leave
Found: Rosso gives it to you after the questioning
Description: It's a police card with his name on it
Used: To dupe many people into thinking that you are a police officer - It is a conversation option
Found: In Flobbage's toolbox
Description: It's used for many things but I believe it is primarily used to remove manholes
Used: Open Manholes - Extra "step" in Ireland
Found: First area of sewers on ground
Description: A regular red clown nose
Used: A clue when describing the clown
Found: Second area of Sewers on ground
Description: It's really greasepaint
Used: A clue when describing the clown - To light pole in Spain
Found: Second area of sewers near ladder
Description: A piece of the clown's costume
Used: A clue when describing the clown
Found: Costume Shop
Description: Put it on your hand and electricute someone!
Used: To shock Khan and make your escape
Found: Hotel Ubu
Description: A key for one of their rooms
Used: To enter the room and sidle to the adjacent room
Found: Khan's Room
Description: An electrician's license
Used: To open the safe in Hotel Ubu - To front as an electrician in Ireland
Found: Hotel Ubu; Khan's Safe
Description: A big map for the Templar Knights
Used: Throughout the game - it's usually with Nico
Found: On Ron's table at the Ireland Bar
Description: It's a rabbit snare but George thinks it is a necklace for a woman.
Used: To fix the bar's pump
Found: Counter from Ireland Bar
Description: A normal towel
Used: Soak it with water and use it in combination with the Plaster of Paris
Found: Cellar of Bar
Description: Generic flashlight that you lose after a couple places
Used: To see in the bar
Found: Cellar of Bar
Description: A pretty gem that Professor Peagram found on his expedition, this is one of the most important and crucial items in the entire game.
Used: Several times, but most notably used in combination with the tripod on the circular area.
Found: Castle In Ireland
Description: A big plow that George can't take
Used: George will move this and get the goat caught in a rope tangled in the plow
Found: Excavation Site in Ireland
Description: It's used to make items out of mold.
Used: In Ireland when you need to make a mold for the door - In the second excavation site (late in the game) to make a key
Found: Cellar of Bar
Description: This towel has been soaked and can be a good source for water.
Used: To finish the mold in the castle
Found: Closet in Hospital
Description: A generic doctor's outfit; it looks convincing
Used: To fool Nurse Grendel and Felix into thinking that you are a doctor
Found: Obtained from Nurse Grendel
Description: Used to take someone's blood pressure
Used: Feed Eric's need to take his blood pressure - Turn off the Lopez's hose in Spain
Found: Obtained from Nico after meeting Andre
Description: One of the most crucial items in the game. The gem fits perfectly on top of it.
Used: With the gem on the circular area
Found: Clown runs and leaves one ball
Description: Just a normal red ball that is used for juggling
Used: Trade with Nejo in Marib for help
Found: Given by Nejo after plan
Description: It's a toilet brush that was formerly used as a basting brush. Sick, I know.
Used: To get inside the bathroom
Found: Obtained from Ultar after giving brush
Description: Keys to the bathroom
Used: To get inside the bathroom, which has two key items
Found: Inside Alamut Club bathroom
Description: A normal towel that is in a locked case
Used: To fix Ultar's truck
Found: Inside Bathroom stall in Marib
Description: Chain used to flush the toilet
Used: A necklace for Nico, or otherwise a really funny joke
Found: Nejo's Stand
Description: It's been broken by the cat
Used: Not much use for it until you put greasepaint on it to make an ancient broken statue
Found: After combining the Broken Statue and Greasepaint
Description: It looks more ancient now that you put greasepaint on it
Used: Barter with Duane to get fifty dollars
Found: After trading with Duane
Description: It's fifty dollars in Syria
Used: To pay for the taxi fair with Ultar
Found: After giving Ultar the towel
Description: It's the other half of the towel
Used: To make a stick-towel
Found: Tree at Bull's Head Hill
Description: Just a regular branch from a tree
Used: To make a stick-towel
Found: After combining the stick and half towel
Description: An interesting device that is made by George
Used: To get down the ledge in Bull's Head Hill
Found: On Klausner's cold, dead body in Bull's Head Hill
Description: A crucial item to the game that makes some things appear differently
Used: Used throughout the game but especially in the church - you have to put it in a scroll
Found: The Countess in Spain
Description: A very old chess set that is missing three chess pieces
Used: - To further progress in the game
Found: Mausoleum
Description: Regular newspaper with horse race words on back
Used: To get the construction worker to leave.
Found: Outside the Excavation Site near the Painter
Description: A pot full of paint - the Painter guards it with his life
Used: To make the key look more "real"
Found: Given by Guard
Description: Keys to restroom and excavation site
Used: If we could make a copy of these keys we'd be all set...
Found: Restroom faucet
Description: Soap... blue soap.
Used: To make the key mold
Found: Made by George
Description: Fake keys made with mold, soap, water, and hot air. George later has to dip it in paint to make it look more like a key
Used: To swap the keys so you can get inside the excavation site without the guard's keys
Found: Lopez's utility room in Spain
Description: A small mirror that could be of some use later in the game
Used: To shed light on the darkness in the well
Found: Mausoleum
Description: Odd looking key that drops from candle
Used: To open a passageway in the well
Found: Under statue in Mausoleum
Description: Just a normal Spanish Bible
Used: To decipher words from tomb in Church
Found: Mausoleum
Description: Really long and slender black pole
Used: To light the center candle in Mausoleum - To close the window in the Mausoleum
Found: Tree near water hose
Description: A Y-Shaped stick used by the Spanish for many centuries to find water
Used: To "find" the hidden well
Found: Lopez automatically stumbles upon it
Description: A really old tin can that dates back to the thirteenth century
Used: Lopez throws it and finds the hidden well
Found: Hidden Well
Description: A fang on the statue of the lion door
Used: To get George killed. - To open the lion door
Found: Nico automatically gets it from Khan
Description: It packs quite a punch but the detonator is missing
Used: At the very end of the game
Found: In Rubble in Britain
Description: A normal pipe used to... y'know
Used: Can be put in demon statue's mouth
Found: In Rubble in Britain
Description: A weird-looking silver coin
Used: None
Found: In Rubble in Britain
Description: It's a small device used to make things rotate
Used: Put in eyes of demon statue
Found: In same place as lever
Description: It's a small device used to make things rotate
Used: Put in eyes of demon statue
Found: A little north of the demon statue
Description: George breaks it off of its device
Used: Put in the statue's mouth and turn it to open the secret door
Found: In same place as lever
Description: I have no idea what this is
Used: None
Found: On Wall in Britain Hidden Passageway
Description: A small medieval-like torch
Used: To light the gunpowder on fire