The game was ported to the Game Boy Advance only in Europe on September 11, 2002, which was developed by Infogrames and published by Sega. Fans criticized this rerelease because of its music being very different compared to the Genesis/Mega Drive version's and having a significantly smaller screen size that allowed much less onscreen. This was said to lessen the effect of seeing into the other frames around the player, making it more like a traditional platform game.
The game is also featured hidden within the Japanese version of Sonic Mega Collection and is an unlockable game in all versions of Sonic Mega Collection Plus, which is unlockable with having a Sonic Heroes game save, or is unlocked after starting all other Mega Drive game at least 50 times. The game is also a part of the Sega Genesis Collection for the PlayStation 2 and PlayStation Portable.
On January 29, 2007, Comix Zone was released for the Wii's Virtual Console.