In addition to weapons, you need to find powerups to assist you in defeating the monsters. You might also need to find switches and/or keys to finish a level.
| Powerup | Effect | Duration |
|---|---|---|
| Bullets, Shells, Rockets, Plasma Cells | Ammunition for weapons | |
| Health potion, Stimpack, Medikit, Soul sphere | 1%, 10%, 25%, and 100% health boosts, respectively (only health potions and soul spheres will boost health above 100%) | Instant |
| Spiritual armor, Security armor, Combat armor | 1%, 100%, and 200% armor boosts, respectively (security armor will not boost the player to over 100%) | Instant |
| Megasphere (Doom II series only) | Boosts both health and armor to maximum (200%) | Instant |
| Radiation suit | Protects against damaging floors. (Some floors can still damage if you stand still on them.) | 60 seconds |
| Berserk pack | Makes fists ten times more powerful, heals player to 100% health if lower upon pickup | Level |
| Backpack | Doubles ammo carrying capacity (only first picked up) and provides some ammo | Episode¹ |
| Computer map | Reveals unexplored areas on in-game map | Level |
| Key | Opens corresponding locked doors; comes in keycard or skull form | Level |
| Light amplification visor | Renders dark areas at full brightness | 120 seconds |
| Partial invisibility | Makes player difficult to see; makes monster aim less accurate | 60 seconds |
| Invulnerability | Provides immunity to damage, player's view (except for sky) becomes extremely bright | 30 seconds |