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West Side - East Side
The Den is a dangerous place and is a safe haven for drug and slave trading. You'll be able to bust a slaver ring and a small gang here.
When you enter the Den, go a bit to the south, and then enter Rebecca's bar/casino (see the note above). Talk to Rebecca, and ask her for some work. She'll tell you to go and find Fred. To find Fred, leave the bar, go south, and enter the building where there is only one orphaned child. Enter it, and talk to the drunk-looking guy (description says that he is "a citizen of the Den"). Tell him that he owes Rebecca $200. He'll ask for $150 in the process, and tell him that's okay. (He'll give you lots of nice stuff later on.) Also, enter the door that leads to Flick, the shopkeeper who is wearing a green shirt. Ask him what he does he do in the Den, and then ask him if you can trade. After he shows you his wares, don't trade for anything, and thank him. Talk to him again and ask him to show you his wares. This time, he has a .44 magnum revolver that you can barter for. Buy that and its corresponding ammunition. Use your gecko pelts to trade for that.
Afterwards, leave this area, and go to Rebecca to pay her the $200. She'll split it in half for you. Talk to Rebecca again and offer to find the missing book for her. The book is in one of four random locations:
After you find the book, you can return it to Rebecca for some experience and money.
Now, it is time to go to the east side. Go there, and if you are female, go to the Hole. Talk to the male bar patron, and tell him that he can screw you for $200. If he says he doesn't have enough money, tell him tough luck and then ask for $200 again (chances are that he might have the money). If you are male, you can screw a prostitute if you give her some cash (I don't know what is the point though...).
Go to the Slavers guild which is to the east. Enter there, and the door guard will start to talk to you. Tell him that you want to see Metzger or you want to buy some slaves. Afterwards, talk to another guard who is holding a slave inside the main building. Ask him about Vic, then ask if you can see him. Beg if the guard won't let you through. If he lets you through, talk to Vic, tell him that you are going to free him, and then give him the old radio that you found in Klamath. Afterwards, go and see Metzger (he's in the center of the northern room). Talk to him, and ask him if you can buy Vic. He'll sell him for $1000. If you're female, you can screw Metzger and buy him for half the price. Also, be sure to steal the shotgun from Metzger.
When you talk to Vic, ask him where did he got the water flasks from for some easy experience.
Next, go to Mom's diner and talk to Mom, the owner of the place. Ask her what's going on in town. She'll hand you a dinner that she wants you to give to Smitty. Also, talk to Stacy and ask her why is she so sad She'll mention a cat, and ask if you can hear the story about her cat. You'll get some experience for listening to the story. Head to the west side of the Den to return Smitty's meal.
Smitty is in the far west corner of the West Side of the Den. Go talk to him, and tell him that you have his meal from Mom's. You'll get 150 experience and a stimpack for giving him the meal. If you take a look at Smitty's lockers, you can get a tool and other miscellaneous items. The last locker contains a shovel, which will be required for a quest later on.
Now it is time to do some mercenary work. Go talk to Lara, who is south of Tubby's store (it's the central building on the western wing of buildings). Lara is the woman in the second room. Talk to her, and ask her if there is any work to be done. She wants you to examine some crates in the Church on the East Side of the Den. Head there.
Once in the East Side, go to the church, and talk to Tyler. Tell him that Metzger sent you, and he wants you to check some stuff for him. He'll get pretty antsy, but will let you in. Once there, examine one column of the crates to find out that they are filled with chemical compounds. Head back to the West Side.
When you go there, go talk to Lara, and tell her what you saw. She'll give you $200 and a new quest: ask Metzger if it is okay for Lara and her gang to guard the church now. Head to Metzger's slave guild. Talk to Metzger and ask if Lara can attack Tyler's gang. Metzger will say that it is okay. Go back to the West Side and talk to Lara. She'll give you another quest: find a weakness in Tyler's gang.
Go back to the church, and talk to Tyler. Ask him what's going on, and he'll mention that he's going to a party. Tell him that you want him to have fun. You'll get more experience. Go back to the West Side. Talk to Lara, and she'll offer you $300 if you go and fight with her in order to eliminate Tyler's gang. Say yes. The fight isn't that bad, especially with Metzger's stolen shotgun and the revolver, and is ridiculously easy with the Power Armor. After you have killed Tyler's gang, you'll receive $400.
Now, it is time to put a ghost to rest. Go to the building that is directly south of the one that Lara usually stays. There should be a ghost there. Talk to the ghost, and ask her what is the matter. The ghost says that she can't find it. Ask the ghost what is the object, and then she'll mention that it is a locket. With this newfound knowledge, go to Mom's diner. Talk to Mom, eat the meal that she offers you, and then ask her if she knows about the haunted house. She'll mention that a teen used the house about two years ago whose name is Joey. Thank her, and head back (sigh) to the West Side.
Joey is the thug wearing a leather jacket. Talk to him, and ask him for some information. Ask him about the ghost, and then ask about the locket. Tell him that he stole it, and buy it from him for $50. With the locket, go back to the building where you found the ghost, and give her the locket. Talk to her again, and she'll turn into a pile of bones. Pick up the bones and head to the graveyard. Find the grave marked "Anna Winslow." Dig up the grave with your shovel, put the bones in there, and then close it up. (If you were wondering, the grave is in the south-eastern area of the graveyard.)
If you have the Advanced Power Armor, you can go and kill Metzger for a good bit of experience. Loot the corpses to get their pistols and drugs, for they come in handy when it comes to buying weapons later on. Also, if you have killed Metzger, go to Rebecca's bar. Tell Rebecca that the fight was easy, and she'll give you $1000 dollars. Go to one of the merchants in the West Side of the Den, and see if you can buy some jet (the merchants might sell it to you for about $60). Head to Vault City now, but stop in the unknown green area while you're on your way there.