Resident Evil 4 is separated into 5 different chapters, each one containing 3 or 4 sub-chapters. The following walkthrough will provide you with directions on where to go and what to do, and also bring you some strategic tips and tricks, all with the least amount of spoilers as possible.
Before you begin, please make sure you familiarize yourself with the control scheme. Being able to control both Leon and Ashley are important factors of your survival.
To jump directly to a specific chapter, please use the Table of Contents.
Important: This walkthrough is not designed to be spoiler-free. Do not continue if you don't want certain parts of the game to be spoiled for you.
To start a new game, choose 'New' from the main menu. If this isn't your first time playing, you'll be asked what difficulty you the game to be in (Normal or Professional), and if you want to change costumes (Normal or Special).
After starting a new game from the main menu, you'll be treated to a short movie summarizing most of the events in the Resident Evil universe so far (at least from Leon's perspective). If you aren't too familiar with the Resident Evil universe, you may want to watch it, but it doesn't contain any new or exciting information.
Then the first in-game cutscenes will begin. It will start with Leon being driven to his destination. There will be some general explanation as to what's going on, and what your objective is, so sit back and watch.
Soon after, the horror finally begins.