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Ten years after the Mansion Incident near Raccoon City, former S.T.A.R.S. operative Chris Redfield has joined the Bioterrorism Security Assessment Alliance (BSAA), a special forces organization funded by pharmaceutical companies dedicated to the investigation and elimination of bioterrorism threats around the world.
Sent to Africa to apprehend a bioweapons dealer, Chris meets up with his new partner Sheva Alomar in the town of Kijuju, where the bioterrorism threat may prove to be more deadly than they ever expected.