Lise is a decent physical attacker and her spells can be quite useful. All of her final classes have five spells: four stat increasing or decreasing spells and a summon that hits all enemies on the screen. Her stat altering spells can be very useful, especially on bosses. Most of her summons can cause status effects in addition to damage.
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Tech: Whirlwind Lance
Spells
She learns no spells until after her first class change. She has decent attack power.
Tech: Vacuum Surge Spear - Multi Target
Spells
Choose the Valkyrie if you want to be able to raise your allies' stats. One advatnage to this choice is that other characters like Hawk (as a Ninja) and Carlie (as a Necromancer) can learn stat lowering spells, but nobody besides Lise can learn all these stat raising spells. If you use the Valkyrie along with a character that can lower stats, you can use both of their spells to make an enormous difference during boss fights.
Tech: Flying Heaven Spear - Multi Target
Spells
Choose the Rune Maiden if you want to be able to lower your enemies' stats. On bosses this is more effective than using stat raising spells because you must cast the stat raising spells three times to hit all your allies, but stat lowering spells only need to be cast once.
Requires Item: Briesingamen
Tech: Light Ball Spear - Multi Target
Spells
Unlike all of Lise's other final classes, the Vanadis has an impressive multi target tech. She also has the highest attack power out of all Lise's classes. Her summon turns enemies mini which makes them extremely easy to kill, but also makes them give 0 experience. It's only good for emergencies. Unfortunately, she cannot cast her stat up spells on all allies simultaneously like the Star Lancer can.
Requires Item: MorningStar Chain
Tech: Shooting Star Spear - Single Target
Spells
The Star Lancer can multi target her stat raising spells which makes it much easier to prepare your party for a tough boss fight. Her summon can silence enemies which prevents many enemies from using their most powerful attacks.
Requires Item: KnightDragon Chain
Tech: Dragon Fang Spear - Single Target
Spells
The Dragon Master has a summon that can poison enemies (which isn't very useful). She does not learn how to multi target her stat down spells.
Requires Item: Gleipnir
Tech: Hundred Flower Dance - Single Target
Spells
The Fenrir Knight's summon, Lamian Naga, does more damage than any of the other summons Lise can learn. The downside is that it is also the only summon that does not cause any status effects. She also learns how to multi target her stat lowering spells, which can be useful when fighting several powerful monsters. For example it is a good idea to cast Power Down on groups of Nightblades to weaken the power of their Split-Image Slice.