Slide Kick: Rick's most powerful attack is also the trickiest move to do in the game. Do a big jump (hold the jump button) while walking either left or right, then as Rick comes down from the jump hold diagonally down-left or down-right and press the attack button just before Rick's feet touch the ground. Use this move to take out many enemies at once and to quickly reach a level's exit but be sure not to slide right into a trap such as a pit, a puddle of vomit, etc.
Save Your Ammo: You can only use your weapons while standing or jumping. This means you are free to kick or even slide kick the enemies in order to save your weapons for tougher enemies in a particular level. Also every time you pick up another weapon, Rick will drop his previous weapon slightly ahead of him allowing you to pick it up again. This is particularly useful against the third stage's boss since you'll be able to easily blow him away with two shotguns.