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Old and new characters return from X-Men Legends, while new faces and characters appear during some levels. Several dialogues in the game will have different text and slightly different dialogue options, depending on whether the speaker is a member of the X-Men or the Brotherhood.
| Playable Characters
|
- Bishop
- Colossus
- Cyclops
- Gambit
- Iceman
- Jean Grey
- Juggernaut
- Magneto
- Nightcrawler
- Rogue
- Scarlet Witch
- Storm
|
| PSP Exclusives
| PC Exclusives
| N-Gage Exclusive
| Unlockable Characters
|
- Cable
- Cannonball
- Dark Phoenix
- X-Man
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|
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- Deadpool
- Iron Man
- Professor X
|
| Villains
|
- Abyss
- Apocalypse
- Archangel
- Bastion
- Cerci Queen
- Dark Beast
- Deadpool
- Garokk
- Grizzly
- Holocaust
- Lady Deathstrike
- Living Monolith
- Madri
- Mikhail Rasputin
- Morlocks
- Mr. Sinister
- Omega Red
- Sauron
- Sugar Man
- Sentinels
- Stepford Cuckoos
- Stryfe
- Zealot
|
† Alternate costume for previous character.