Resident Evil 4/Chapter 4-4

Colossus
You're now inside a cathedral-like building; the tower you're trying to get to is on the left somewhere. Follow the hall a bit to find two Handgun Ammo refills and a typewriter; there not much point to saving now through since there was a save at the end of the last chapter.

Continue and find a giant statue of Salazar. It's quiet for the moment so explore a bit to get the layout, but don't start down the path over the water just yet. One either side of the statue are structures with three levels and there is a platform at midlevel in front of it. You enter on the lower level of the statue's left but most of the rest isn't accessible now.

Start walking down the path over the water and a zealot leader appears and pulls a lever; this lowers the path so you can't cross (wading/swimming being out of the question), and starts the statue moving. For now, just its left hand moves and it makes a kind of lift to get from the second level to the third level on the left side. You can also use it as a stepping stone to hop over to the platform in front of the statue. Other zealots appear in various places.

It's tempting to go after the zealot leader inside the cage on the right side, but just ignore him for the moment. Go up the ladder on the right side, then stay there and fight zealots as they use the hand to get down to you from above. Beware of the occasional zealot who climbs up the ladder after you. Now use the hand to get to the top level and take out the archer and any other zealots there. There is a mechanism here but ignore if for now and use the hand to get to the platform in front of the statue. Activate the switch here and the statue's right hand starts to move. Stay there and fend off zealots who jump onto the platform with you. One of them might be the zealot leader and if so then defeat him now; if you did it earlier when he was in the cage then you wouldn't get his sizable 5000 PTAS drop. If you drop to the ground and need to get the statue's left hand moving, just shoot the lever.

Use the right hand to get to the top level and from there to a ledge near the statue's head. Go around to the back and pull the lever. Now the statue's hands are both moving in a more complicated pattern that allows you to reach all the levels on either side. Clear out any remaining zealots.

Now that the area is quiet again, search for items.
 * Two pots on the left side lower level
 * A pot on the left side middle level
 * Two pots on the left side upper level
 * A pot behind the statue's head
 * A pot on the right side lower level
 * Two pots on the right side middle level
 * A pot on the right side upper level

Operate the lever on the top level on the left and clear out the zealots that appear. Now do the lever the lower level on the right; a group of zealots appears right next to you but an Incendiary Grenade will take care of them quickly. Other zealots appear including an archer on the left side so clear the area again, or not since there's not really anything else you need to do here.

The path over the water is now restored, but before crossing get out your rifle scope and zoom in on the door on the far side, then snipe the lock on the door; this will save you a second or two later when it will be important. If you don't have a scope then don't worry about it.

You can easily switch up the order you do things here, for example pull the lever on the left as soon as you get to it; the major difference will be that you may have to fend off more zealots at once. But if you'd rather just avoid them instead of fighting then it's a better way to go. The upper floor on the right side and the switch behind the statue's head is optional.

You may want to go back to the typewriter and save at this point because it will be a while before the next one.

Start down the path when the area is clear. The statue will start to move and chase you, knocking down pillars in its wake. Press the button shown on the screen to run and watch for other buttons to appear dodge falling debris. If you haven't already, shoot the lock on the door at the end to unlock it, or better, snipe it before you start, and go through.

The statue breaks through the giant door and you have to keep sprinting until it collapses under it’s own weight. Then do a final button combination to jump to the other side of the chasm and press another button to pull yourself up.

If you have trouble getting enough time for the final jump then there are a couple things you can try. First, if you use a continue instead of reloading you seem to get a bit more time. Second, if you interrupt the short cutscene between when you exit the door and when you start running again then you get that additional time. There are a few other factors which may make this easy or difficult such as the version you're playing and the controller you're using.

There’s no going back now so enter the tower up ahead.