Each playable species has its own unique weapon selection:
The human's weapon selection is as follows:
- Combat knife
- M4A4 Pistol (Has an uncanny resemblance to the real-life Heckler & Koch Mk23 pistol.)
- M41A Pulse Rifle
- M-92 Grenade launcher
- M56 Smart Gun
- M-6B Rocket Launcher
- M-90 Minigun
- WY-102 Sniper rifle
- M240 Flamethrower
Humans recover health by picking up medical packs, and can further protect against harm by picking up armor.
The Predator's weapon selection is as follows:
- Plasma Pistol
- Smart disc
- Remote bombs
Predators also have a Medicomp device that allow them to heal themselves, and an Energy Sift device that allows them to recover energy for their equipment.
Aliens can only perform melee attacks with their claws, stunning tail whip, and via pounce attacks. However, this limited range of "weaponry" is augmented by impressive physical skills: they are able to climb walls at any inclination, and make better-than-human jumps. To heal, they must eat from the body of a Predator or human. This is done by clawing at the bodies of their opponents, with the most health coming from executing a successful head-bite of an opponent (this also works on corpses)which makes them very good in a campaign.