As part of Sketch's travel into Comix Zone, he takes the hero's role in the story, giving him access to typical superhero fighting skills far beyond his regular abilities. If he attacks an immobile object, Sketch's health will diminish slightly, meaning that if he is low on health other tools such as explosives should be used to continue instead. One power-up – a collectible fist – temporarily transforms Sketch into Super Sketch, who shreds the page and destroys all enemies and obstacles in his path.
Sketch is capable of tearing shreds out of the backdrop and folding them into paper planes to throw at enemies as a weapon. Because this paper world is also part of everything within Comix Zone (as they are drawn on it), this action takes a significant slice off the player's health bar. Certain combos will send enemies hurtling, and if a fragile border between frames is in the way, the enemy crashes through it, tearing it to shreds. When confronted with an unbreakable frame barrier, the hero merely swings himself out of the frame, over the top of the border, and back down into the next scene. Sketch's pet rat Roadkill (whom he saved from certain doom in a garbage truck) is also capable of operating switches and discovering items hidden in panels, making him useful in helping Sketch's progress through Mortus' traps. Roadkill can be deployed to electrocute enemies or pull switches in low clearing areas, which Sketch might otherwise not be able to reach.
Mortus does intend to give Sketch a "sporting chance". After the first page, if Sketch dies, Mortus will allow Sketch another chance to complete the page from the first panel, stating "Oh, come on -- that was just too easy!" After the second page, Sketch will get one more chance. If Sketch still has a chance at completing the game, his last words will be "Is this the end of the story?" If he has no such chances, his last words will simply be "Game over, man. The end." If Sketch ever dies before reaching the final panel, Mortus will turn from ink and paper to flesh and bone, and announces, "I'm going to rock this world!"