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The weapons listed below are provided in the order in which they are likely to be found in the game. This includes the Super Weapons acquired by winning the secret areas.

The Mighty Boot – Duke extends his foot in a kick. Useful for breaking open boxes or weak crates without wasting ammo.

Throwing Knife – A weak weapon by appearance, but a well thrown knife can take out an enemy in 1 or 2 hits.

Throwing Axe

Crossbow – A long-range firing weapon, this is basically the medieval version of the Buffalo Rifle.

Desert Eagle – Duke's trusty sidearm.

Combat Shotgun – A powerful gun that can tear limbs apart;useful when wandering about stages.

Buffalo Rifle – A gun found in the Old West, it can do some fairly good damage for long-range firing.

Gatling Gun – Another competent roaming weapon with an extremely high-firing rate.

Rocket Propelled Grenade/RPG (Rocket Launcher) One of the most powerful weapons Duke gains possession of. Basically, this is a rocket launcher which can wipe out almost all enemies within view.

Flamethrower – At short range, this weapon can roast any adversary.

'Energy Zapper This weapon fires a short-range 'claw' which can 'seek' out a nearby enemy, latch on, and holds them until they burn up.

Freezer – Works exactly like the Freezethrower from Duke Nukem 3D.

Pipe Bombs

Holy Hand Grenade – Straight out of Monty Python and the Holy Grail, these explosives are far more useful than dynamite and pipe bombs.

Dynamite – A weapon similar to the pipe bomb, but lights immediately and should be thrown quickly.