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The game defaults are set for right-handed players. There is an option available in the menu for left-handed players that want to play the guitar left-handed (right hand on the colored neck buttons, left hand strumming/picking).

The following table maps the various system controllers to the guitar controller for those that want to play without a guitar.

Wii PlayStation 2 and 3 Xbox360 Guitar
B button R1 button LT button Green control
Up dpad R2 button LB button Red control
A button L1 button RB button Yellow control
1 button L2 button RT button Blue control
2 button Cross button A button Orange control
ShakeRemote button Neutral lstick Neutral lstick or Neutral rstick Whammy control
Left dpad Select button Back button Tilt control
Plus button Start button Start button Pause the game
A button Cross button A button Confirm
B button Square button B button Cancel
Neutral dpad Neutral dpad Neutral dpad Navigate Menus

Notes:

  • The Wii remote needs to be held sideways. You should shake the wii remote up and down for a better whammy effect.
  • When using the guitar controller, Green control and Red control are normally used for Confirm/Cancel.