- Joystick: Use the 8-way joystick to direct the player who currently has the red (for 1P and 2P) or blue (for 3P and 4P) arrow with your player number above him around the field, and select plays on the play selection screen (which you will actually be seeing more of than the field itself in this game!).
- Action Button: Use this button to build up power for a kick-off (or a punt), switch control to the next available player (indicated by the arrow with your player number on it), pass the ball to the next available player (which will also result in control being switched to him), jump while running and confirm your plays upon the play selection screen; in a 3- or 4-player game, both players on one side must confirm their play by pushing their Action Buttons.
- 1, 2, 3 or 4 Player Buttons: Push these buttons to begin the game as player 1, player 2, player 3 or player 4; if both of the players on either side are not present, the CPU-controlled team shall be randomly-generated (but like in World Stadium, the difference between the teams is purely graphical).
There are fifteen different teams to choose from in this game: Atlanta, Chicago (Williams Electronics' home town), Denver, Detroit, Kansas City, Los Angeles (LA), Miami, New York, Pittsburgh, San Francisco (San Fran), Texas, Washington, Team Africa, Team Canada and Team Europa; but, as mentioned above, the difference between them is graphical. None of the players are named, either - and they all have a number 88 on their jerseys.
The outfits of San Francisco and Team Europa are also identical, so if one or two players choose to control either of those teams and the CPU randomly selects the other one to control, or three or four players intentionally choose to control both of them, that could end up causing a great deal of confusion.