Enjoy Your Powers[edit]
This is earned for unlocking all previous trophies.
Unstoppable[edit]
Expert difficulty isn't that much harder than the default difficulty. One thing that many may find hard is the final boss. My only recommendation is to, prior to starting the mission, obtain as many upgrade points as possible. They should then be spent in upgrading concrete, the only power available during the battle. Otherwise, you probably won't notice a considerable change in difficulty.
Sacrifice
This is a quite easy one, and should be earned on your Good Karma playthrough. In The Visitors, once you've chased Hank out of the fish guttery, Augustine will stop Hank, and start questioning you, even resorting to torture. For this trophy, pick "Turn yourself in", and confirm the option with 
button. This will initiate your Good Karma playthrough.
Ruthless
See the above, except pick "Sacrifice the tribe". This will initiate your Evil Karma playthrough.
Temperance
At the end of Go Fetch, Reggie will restrain Fetch. You can choose whether to Redeem or Corrupt Fetch. For this trophy, choose "Redeem Fetch". This will unlock the Good mission Trash the Stash after you complete Light It Up.
Malice
See the above, except pick "Corrupt Fetch". This will unlock the Evil mission Fight Intolerants after you complete Light It Up.
Courage
After the mission Reggie Takes Flight, you will fight Eugene (He Who Dwells), and you can choose whether to Redeem or Corrupt Eugene. For this trophy, choose "Redeem Eugene". This will unlock the Good mission Flight of Angels after you complete Zero to Hero.
Contempt
See the above, except pick "Corrupt Eugene". This will unlock the Evil mission Hunting the Hunters after you complete Zero to Hero.
Mercy
In the mission Smoke and Mirrors, you will chase Hank, and at the end you can choose whether to Spare or Kill him. For this trophy, choose "Spare Hank". Unlike the others, this simply gives you Karma, and doesn't unlock a different mission.
Revenge
See the above, except pick "Kill Hank".
Justice
Simply complete the Good final mission, Expose Augustine.
Dominance
Simply complete the Evil final mission, Kill Augustine.
Reconciliation[edit]
Simply complete the final mission with Good Karma. This will unlock after the credits finish.
Rebellion[edit]
Simply complete the final mission with Evil Karma. This will unlock after the credits finish.
Everybody Out[edit]
Suspicion pens are marked with a blue padlock on the map. They are basically a large yellow cage with civilians inside. For this trophy, go over to the door and use the touchpad to rip it off and free the suspects. Repeat this with 9 other cages to earn this trophy.
Spin-off[edit]
Sign twirlers are marked with the red icon a sign. Be sure not to alert anyone by using your powers, as they will likely disperse, and you will not be able to kill the twirler. Simply shoot the twirler and repeat this with 9 other musicians to earn this trophy.
Everyone's a Critic[edit]
Street musicians are marked with the red icon of a music note. Like with the above, be careful not to alert anyone, because that will cause the musician to drop his instrument and run.
Just Say No[edit]
Drug dealers are marked with a blue icon of a syringe. The description is kind of inaccurate, considering that you need to perform 10 drug busts, not bust 10 individual dealers. To do this, you need subdue all of the dealers guarding the drugs, and then destroy the drugs. Make sure it says "Drug Bust", to confirm that you have performed a drug bust. Do 10 of these for the trophy.
Freedom of Speech[edit]
Activists are marked with a red, strucken-through circle. This is quite simple, locate the activists and kill one of them to disrupt it (or simply fire a missile into the group). Do this with ten rallies for your trophy.
What Did You Call Me?[edit]
Another dodgy description. "Obnoxious" members are usually isolated. You'll know when you kill one when it says "Akuran silenced" in the Karmic feed. Do this with 10 gang members for the trophy. There is usually only one "obnoxious" member per group.
Someone Your Own Size[edit]
In the second island, you will see suspected conduits in yellow vests, simply walk over to them and press 
to rescue them. Do this with 10 suspects for the trophy.
Walk It Off[edit]
You'll see frequently see injured civilians around the map, usually after a fight between you and the DUP. To heal them, simply press when next to them. Do this with 10 wounded civilians for the trophy.
Kicking and Screaming[edit]
This is probably one of the first trophies you will get on your Evil Karma playthrough. Whenever you see an enemy surrendering, simply press 
to execute them. When you see wounded civilians, simply press to execute them.
True Hero[edit]
Simply gain Level 5 Good Karma (True Hero). You can gain good Karma by:
- Choosing "Good" (blue) choices within the story.
- Subduing DUP troopers.
- Subduing surrendering enemies.
- Healing injured civilians.
- Performing drug busts (subduing the dealers and destroying the drugs).
- Subduing enemies with Neon (requires an upgrade, listed in the powers section).
- Freeing suspected conduits from suspicion pens.
- Rescuing suspected conduits being assaulted by mobs (second island only).
You're likely to have Level 3 or 4 either karma by the time you finish the game, so you won't need to grind. You will definitely get it before you get all the other trophies.
Infamous[edit]
Simply gain Level 5 Evil Karma (Infamous). You can gain evil Karma by:
- Choosing "Evil" (red) choices within the story.
- Executing surrendering enemies.
- Executing injured civilians.
- Killing police and civilians.
- Disrupting activist rallies.
- Killing street musicians.
- Killing DUP troopers.
- Destroying suspicion pens.
- Killing Akuran gang members (second island only).
- Executing suspected conduits being assaulted by mobs (second island only).
- Killing enemies with Neon (requires an upgrade, listed in the powers section).
Bweep! Bweep! Bweep![edit]
See below.
Shardcore[edit]
This is easier than collectables in other games, as they will appear as blue dots on your map after you destroy the DUP mobile command in a district. Simply collect all of these, and you're done!
Nothing To See Here[edit]
Blinded[edit]
Inside Track[edit]
Blown Cover[edit]
Big Brother[edit]
Coloring Inside the Lines[edit]
Prank Call[edit]
Hello Operator[edit]
Final Showdown[edit]
One Down[edit]
Home Field Advantage[edit]
Clean Sweep[edit]
Total CARnage[edit]
Drop Everything[edit]
Keep It Up[edit]
Put That Anywhere[edit]
Hat Trick[edit]
Double Smoke Stack Attack[edit]
Cough Drop[edit]
Make Fetch Proud[edit]
Excessive Force[edit]
