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Name Voice actor Description
Tony Stark/Iron Man Robert Downey Jr. A billionaire industrialist, genius inventor, and consummate playboy, he is CEO of Stark Industries, a chief weapons manufacturer for the U.S. military. He builds a suit of power armor to escape the Ten Rings terrorists after being kidnapped while performing a weapons test in Afghanistan and decides to help mankind as Iron Man.
Lieutenant Colonel James Rhodes Terrence Howard A pilot friend of Stark, and the liaison between Stark Industries and the military in the department of acquisitions. He assists the Iron Man in his fight against Maggia and A.I.M.
Dr. Ho Yinsen Shaun Toub Stark's fellow captive in Afghanistan, Yinsen is a surgeon who has traveled the world and was kidnapped by the Ten Rings terrorist group. He saves Stark from death when Stark was injured by shrapnel, and uses an electromagnet to suspend the shards he couldn't remove before they reach Stark's heart. He assists Stark in creating his armor and keeping it a secret from their captors. He also acts as Stark's mentor and his death was one of the principal reasons behind Stark's decision to change the direction of his company.
Obadiah Stane/Iron Monger Fred Tatasciore Stark Industries' second-in-command, who wants total control of the company. When Stark declares he will no longer manufacture weapons, Stane steals the blueprints for the Mark I armor to create his own, bigger version. He starts working with A.I.M. and steals Stark's arc reactor to create a power source for his armor. The Iron Monger later confronts the Iron Man atop Stark Industries and is defeated.
Pepper Potts Meredith Monroe Tony Stark's personal secretary and budding love interest. She helps the Iron Man when he decides to destroy all Stark Industries weapons stockpiles.
J.A.R.V.I.S. Gillon Stephenson Tony Stark's personal A.I., which assists him in the construction and programming of the Iron Man suit. He also acts as Stark's guidance system and helps him every time.
Boris Bullski/Titanium Man Dimitri Diatchenko An ex-KGB member and now agent of Advanced Idea Mechanics, Bullski created a titanium armor similar to Tony Stark's Iron Man suit, even capable of generating a force field and energy blasts. He confronted Stark in a nuclear plant in Russia and later at the Stark Industries facilities. The Titanium Man was defeated in both occasions.
Bruno Horgan/Melter Gavin Hammon Horgan was once an industrialist who specializes in providing munitions to the United States government, and a competitor of Stark Industries. After declaring bankruptcy, he discovered that one of his faulty devices is capable of casting a beam capable of "melting" anything composed of iron. Horgan then adopts the alias the "Melter", and starts working with Advanced Idea Mechanics, building a giant proton cannon in one of their islands. The Melter later confronts the Iron Man in a room under the destroyed cannon, and is defeated.
Marc Scarlotti/Whiplash Zach McGowan After being fired by Stark Industries, Scarlotti starts working with Maggia to get revenge on Tony Stark. He possesses the ability to stretch his arms as well as firing energy from his hands, and can also create a shield around himself. He encountered the Iron Man when he was destroying the Ten Rings weapons stockpiles in Afghanistan and was defeated after a brief battle.
Whitney Frost/Madame Masque Courtenay Taylor One of the Maggia families leader, who have previously had a relationship with Tony Stark. When the Iron Man attacked her mansion to destroy their weapons stockpiles, she confronted him, and was killed by fallen debri.
Basil Sandhurst/Controller An A.I.M. agent, the Controller commanded an attack on a U.S. military ship in the Artic. When the Iron Man tried to stop his actions, the Controller used his powers to confuse him. However, Stark manages to outsmart him and stop his attack.
Raza The terrorist who orders Tony Stark to build a Stark Industries missile system for his organization, the Ten Rings. He confronted the armored Stark during his escape attempt.