- Elecman: there are few enemies in his stage, and the special weapons would have little use.
- Iceman: some enemies are difficult to defeat using just the Mega Buster.
- Fireman: one item can be obtained only using Iceman's Ice Slasher.
- Cutman: several enemies are immune to the Mega Buster, but can be stunned or defeated using other weapons.
- Teleport System & Enker
- Dr. Wily