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| Item | Image | Description | Location |
|---|---|---|---|
| Potion | Restores the HP of a POKéMON by 20 points. | At Poké Marts everywhere | |
| Antidote | Heals a poisoned POKéMON. | At Poké Marts everywhere, Pickup ability | |
| Burn Heal | Heals POKéMON of a burn. | At Poké Marts everywhere | |
| Ice Heal | Defrosts a frozen POKéMON. | At Poké Marts everywhere | |
| Awakening | Awakens a sleeping POKéMON. | At Poké Marts everywhere | |
| Parlyz Heal | Heals a paralyzed POKéMON. | At Poké Marts everywhere | |
| Full Restore | Fully restores the HP and status of a POKéMON. | Pick-up | |
| Max Potion | Fully restores the HP of a POKéMON. | ||
| Hyper Potion | Restores the HP of a POKéMON by 200 points. | ||
| Super Potion | Restores the HP of a POKéMON by 50 points. | Pick-up | |
| Full Heal | Heals all the status problems of one POKéMON. | Pick-up | |
| Revive | Revives a fainted POKéMON with half its HP. | Pick-up | |
| Max Revive | Revives a fainted POKéMON with all its HP. | ||
| Fresh Water | A mineral water that restores HP by 50 points. | Lilycove Dept Store, top floor | |
| Soda Pop | A fizzy soda drink that restores HP by 60 points. | Lilycove Dept Store, top floor | |
| Lemonade | A very sweet drink that restores HP by 80 points. | Lilycove Dept Store, top floor | |
| Moomoo Milk | A nutritious milk that restores HP by 100 points. | ||
| EnergyPowder | A bitter powder that restores HP by 50 points. | Herb Shop, Lavaridge Town | |
| Energy Root | A bitter root that restores HP by 200 points. | Herb Shop, Lavaridge Town | |
| Heal Powder | A bitter powder that heals all status problems. | Herb Shop, Lavaridge Town | |
| Revival Herb | A very bitter herb that revives a fainted POKéMON. | Herb Shop, Lavaridge Town | |
| Ether | Restores the PP of a selected move by 10. | ||
| Max Ether | Fully restores the PP of a selected move. | ||
| Elixir | Restores the PP of all moves by 10. | ||
| Max Elixir | Fully restores the PP of a POKéMON's moves. | ||
| Lava Cookie | A local specialty that heals all status problems. | Mt. Chimney | |
| Blue Flute | A glass flute that awakens sleeping POKéMON. | Glass Workshop | |
| Yellow Flute | A glass flute that snaps POKéMON out of confusion. | Glass Workshop | |
| Red Flute | A glass flute that snaps POKéMON out of attraction. | Glass Workshop | |
| Black Flute | A glass flute that keeps away wild POKéMON. | House in Route 113 | |
| White Flute | A glass flute that lures wild POKéMON. | House in Route 113 | |
| Berry Juice | A 100% pure juice that restores HP by 20 points. | ||
| Sacred Ash | Fully revives and restores all fainted POKéMON. | ||
| Shoal Salt | Salt obtained from deep inside the SHOAL CAVE. | ||
| Shoal Shell | A seashell found deep inside the SHOAL CAVE. | ||
| Red Shard | A shard from an ancient item. Can be sold cheaply. | ||
| Blue Shard | A shard from an ancient item. Can be sold cheaply. | ||
| Yellow Shard | A shard from an ancient item. Can be sold cheaply. | ||
| Green Shard | A shard from an ancient item. Can be sold cheaply. | ||
| HP Up | Raises the base HP of one POKéMON. | ||
| Protein | Raises the base ATTACK stat of one POKéMON. | ||
| Iron | Raises the base DEFENSE stat of one POKéMON. | ||
| Carbos | Raises the base SPEED stat of one POKéMON. | ||
| Calcium | Raises the base SP. ATK stat of one POKéMON. | ||
| Rare Candy | Raises the level of a POKéMON by one. | ||
| PP Up | Raises the maximum PP of a selected move. | ||
| Zinc | Raises the base SP. DEF stat of one POKéMON. | ||
| PP Max | Raises the PP of a move to its maximum points. | ||
| Guard Spec. | Prevents stat reduction when used in battle. | ||
| Dire Hit | Raises the critical-hit ratio during one battle. | ||
| X Attack | Raises the stat ATTACK during one battle. | ||
| X Defend | Raises the stat DEFENSE during one battle. | ||
| X Speed | Raises the stat SPEED during one battle. | ||
| X Accuracy | Raises accuracy of attack moves during one battle. | ||
| X Special | Raises the stat SP. ATK during one battle. | ||
| Poké Doll | Use to flee from any battle with a wild POKéMON. | ||
| Fluffy Tail | Use to flee from any battle with a wild POKéMON. | Lilycove Dept. Store | |
| Super Repel | Repels weak wild POKéMON for 200 steps. | At PokéMarts everywhere | |
| Max Repel | Repels weak wild POKéMON for 250 steps. | At PokéMarts everywhere | |
| Escape Rope | Use to escape instantly from a cave or a dungeon. | At PokéMarts everywhere | |
| Repel | Repels weak wild POKéMON for 100 steps. | At PokéMarts everywhere | |
| Sun Stone | Makes certain species of POKéMON evolve. | Six Island Ruin Valley, Mossdeep City | |
| Moon Stone | Makes certain species of POKéMON evolve. | Mt. Moon, Rocket Hideout, Two Island, Wild Clefairy, Meteor Falls | |
| Fire Stone | Makes certain species of POKéMON evolve. | Celadon City Department Store, Mt. Ember, Trade a Red Shard for one at the Treasure Hunter's House on Route 124, Fiery Path, S.S. Libra, Talk to person in Gateon Port. | |
| Thunderstone | Makes certain species of POKéMON evolve. | Celadon City Department Store, Power Plant, Trade a Yellow Shard for one at the Treasure Hunter's House on Route 124, New Mauville, Talk to person in Gateon Port | |
| Water Stone | Makes certain species of POKéMON evolve. | Celadon City Department Store, Abandoned Ship, Seafoam Islands, Talk to person in Gateon Port | |
| Leaf Stone | Makes certain species of POKéMON evolve. | Celadon City Department Store, Route 119, Trade a Green Shard for one at the Treasure Hunter's House on Route 124, Safari Zone (Fuchsia City). | |
| TinyMushroom | A plain mushroom that would sell at a cheap price. | ||
| Big Mushroom | A rare mushroom that would sell at a high price. | ||
| Pearl | A pretty pearl that would sell at a cheap price. | ||
| Big Pearl | A lovely large pearl that would sell at a high price. | ||
| Stardust | Beautiful red sand. Can be sold at a high price. | ||
| Star Piece | A red gem shard. It would sell for a very high price. | ||
| Nugget | A nugget of pure gold. Can be sold at a high price. | ||
| Heart Scale | A lovely scale. It is coveted by collectors. | ||
| Orange Mail | A ZIGZAGOON-print MAIL to be held by a POKéMON. | Poké Mart in Petalburg, Trick House | |
| Harbor Mail | A WINGULL-print MAIL to be held by a POKéMON. | Poké Mart in Slateport, Trick House | |
| Glitter Mail | A PIKACHU-print MAIL to be held by a POKéMON. | Trick House | |
| Mech Mail | A MAGNEMITE-print MAIL to be held by a POKéMON. | Lilycove Dept. Store, Trick House | |
| Wood Mail | A SLAKOTH-print MAIL to be held by a POKéMON. | Poké Mart in Fortree, Trick House | |
| Wave Mail | A WAILMER-print MAIL to be held by a POKéMON. | Lilycove Dept. Store, Trick House | |
| Bead Mail | MAIL featuring a sketch of the holding POKéMON. | Trick House | |
| Shadow Mail | A DUSKULL-print MAIL to be held by a POKéMON. | Poké Mart in Sootopolis, Trick House | |
| Tropic Mail | A BELLOSSOM-print MAIL to be held by a POKéMON. | Trick House | |
| Dream Mail | MAIL featuring a sketch of the holding POKéMON. | ||
| Fab Mail | A gorgeous-print MAIL to be held by a POKéMON. | ||
| Retro Mail | MAIL featuring the drawings of three POKéMON. | held by Meowth from in-game trade at the Battle Frontier | |
| BrightPowder | A hold item that casts a glare to reduce accuracy. | Battle Tower | |
| White Herb | A hold item that restores any lowered stat. | Route 104 | |
| Macho Brace | A hold item that promotes growth, but reduces SPEED. | Route 111, The Winstrate's House | |
| A hold item that gets EXP. points from battles. | Received from Devon Corp. President | ||
| Quick Claw | A hold item that occasionally allows the first strike. | Trainer School | |
| Soothe Bell | A hold item that calms spirits and fosters friendship. | Slateport Pokemon Fan Club | |
| Mental Herb | A hold item that snaps POKéMON out of infatuation. | Fortree City | |
| Choice Band | Raises a move's power, but permits only that move. | Battle Tower | |
| King's Rock | A hold item that may cause flinching when the foe is hit. | Pickup Ability, Seven Island Sevault Canyon, Mossdeep City | |
| SilverPowder | A hold item that raises the power of BUG-type moves. | Route 120 | |
| Amulet Coin | Doubles money in battle if the holder takes part. | Received from Mom after getting Dad's Gym badge (5th gym) | |
| Cleanse Tag | A hold item that helps repel wild POKéMON. | Mt. Pyre | |
| Soul Dew | Hold item: raises SP. ATK & SP. DEF of LATIOS & LATIAS. | Needs Mystic Ticket From Nintendo event | |
| DeepSeaTooth | A hold item that raises the SP. ATK of CLAMPERL. | Give Mr. Brinney the Scanner (received from the Abandoned Ship) in Slateport City and he will give you one. Choice between this or DeepSeaScale | |
| DeepSeaScale | A hold item that raises the SP. DEF of CLAMPERL. | Give Mr. Brinney the Scanner (received from the Abandoned Ship) in Slateport City and he will give you one. Choice between this or DeepSeaTooth | |
| Smoke Ball | A hold item that assures fleeing from wild POKéMON. | Trick House | |
| Everstone | A wondrous hold item that prevents evolution. | Granite cave | |
| Focus Band | A hold item that occasionally prevents fainting. | Received from Black Belt in Shoal Cave (Low Tide) | |
| Lucky Egg | A hold item that boosts EXP. points earned in battle. | ||
| Scope Lens | A hold item that improves the critical-hit rate. | Battle Tower | |
| Metal Coat | A hold item that raises the power of STEEL-type moves. | Held by Magneton on XD, wild Pokémon, Five Island Memorial Pillar | |
| Leftovers | A hold item that gradually restores HP in battle. | S.S Tidal | |
| Dragon Scale | A strange scale held by DRAGON- type POKéMON. | Wild Pokémon, Six Island Water Path | |
| Light Ball | A hold item that raises the SP. ATK of PIKACHU. | Found on wild Pikachu (5% chance) | |
| Soft Sand | A hold item that raises the power of GROUND-type moves. | Slateport Beach | |
| Hard Stone | A hold item that raises the power of ROCK-type moves. | Trick House | |
| Miracle Seed | A hold item that raises the power of GRASS-type moves. | Petalburg Forest | |
| BlackGlasses | A hold item that raises the power of DARK-type moves. | Rusturf Tunnel | |
| Black Belt | A hold item that boosts FIGHTING- type moves. | Route 115 | |
| Magnet | A hold item that boosts ELECTRIC- type moves. | Trick House | |
| Mystic Water | A hold item that raises the power of WATER-type moves. | Weather Institute (Castform) | |
| Sharp Beak | A hold item that raises the power of FLYING-type moves. | Wild Doduo and Dodrio | |
| Poison Barb | A hold item that raises the power of POISON-type moves. | Wild Cacnea and Roselia | |
| NeverMeltIce | A hold item that raises the power of ICE-type moves. | Shoal Cave Bottom Floor | |
| Spell Tag | A hold item that raises the power of GHOST-type moves. | Wild Duskull and Dusclops | |
| TwistedSpoon | A hold item that boosts PSYCHIC- type moves. | Wild Abra | |
| Charcoal | A hold item that raises the power of FIRE-type moves. | Lavaridge Town herb shop | |
| Dragon Fang | A hold item that raises the power of DRAGON-type moves. | Meteor Falls | |
| Silk Scarf | A hold item that raises the power of NORMAL-type moves. | Dewford Town | |
| Up-Grade | A peculiar box made by SILPH CO. | Five Island Rocket Warehouse, Rocket Warehouse | |
| Shell Bell | A hold item that restores HP upon striking the foe. | Shoal Cave, Route 125 | |
| Sea Incense | A hold item that slightly boosts WATER-type moves. | Mt. Pyre | |
| Lax Incense | A hold item that slightly lowers the foe's accuracy. | Mt. Pyre | |
| Lucky Punch | A hold item that raises CHANSEY's critical-hit rate. | ||
| Metal Powder | A hold item that raises DITTO's DEFENSE. | ||
| Thick Club | A hold item that raises CUBONE or MAROWAK's ATTACK. | ||
| Stick | A hold item that raises FARFETCH'D's critical-hit ratio. | ||
| Red Scarf | A hold item that raises COOL in CONTESTS. | Fan Club, Slateport, needs a Pokémon with a high Cool stat | |
| Blue Scarf | A hold item that raises BEAUTY in CONTESTS. | Fan Club, Slateport, needs a Pokémon with a high Beauty stat | |
| Pink Scarf | A hold item that raises CUTE in CONTESTS. | Fan Club, Slateport, needs a Pokémon with a high Cute stat | |
| Green Scarf | A hold item that raises SMART in CONTESTS. | Fan Club, Slateport, needs a Pokémon with a high Clever stat | |
| Yellow Scarf | A hold item that raises TOUGH in CONTESTS. | Fan Club, Slateport, needs a Pokémon with a high Tough stat |