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You can play it in three ways, Wii Remote and Nunchuk, just the Wii Remote and the Wii Zapper. Before you play the game, choose your favorite control scheme in the option menu.

Remote Nunchuck Zapper Action
B button Fire. If your gun has no ammo, you can press it to recharge it.
A button Z button Action / Confirm.
A hold Z button Z button Knife attack. Swipe it straight across the screen for this effect. Also for auto-lock on easy mode only.
Plus button Minus button Use herbs or recover health.
Minus button C button 1 button Status Screen.
1 button Pause.
Neutral dpad Neutral nunchuk Change weapons.
Shake remote Reload weapon.