Once all three Ghostbusters, and Slimer for the one who beamed up either Green Ghost ghost, have reappeared on the screen, eight Type 11 enemies shall appear (four on either side of the screen) and start walking towards you while spitting projectiles at you; once you have fired a shot at each of them to kill them they shall leave eight ghosts behind. Once you have beamed them all up you will have to walk up as you come to two Type 16 enemies who are spitting flames at you from their positions on a wall - and once you have fired enough shots at both of these to kill them, for 2500 points apiece (they shall not leave ghosts behind), you shall have to walk to the right and up over two angry-looking spikes (while they have receded into the ground) as six Type 15 enemies come walking down towards you from the top of the screen, while throwing axes at you. Once you have fired enough shots at each of these to kill them for 100 points apiece, they will leave six more ghosts behind; once you have beamed them all up, you will have to walk to the left and up, then fire enough shots at each of three vases to destroy them (but if your Ghostbuster is standing directly in front of one, his shots will pass over it).
You shall then have to continue walking up, as a Type 14 enemy comes walking down towards you from the top of the screen while extending his head towards you; once you've fired enough shots at him to kill him he'll leave a fifteenth ghost behind. Once you have beamed him up, two Type 1 enemies will come flying up towards you from the bottom of the screen while sticking their tongues out at you - and once you've fired one shot at both of them to kill them, they'll leave two more ghosts behind. Once you have beamed both of them up, five Type 3 enemies will come flying towards you from the left side, right side and bottom of the screen while spitting projectiles at you; once you've fired a shot at each of them to kill them they shall leave five more ghosts behind (one of which has an Aura Power powerup inside). Once you've beamed them all up a third protective barrier shall appear around your Ghostbuster for a short period of time - and you shall now have to continue walking up as you come to a third Type 16 enemy who is spitting flames at you from his position on another wall. Once you've fired enough shots at him to kill him you shall have to walk to the right over two more angry-looking spikes (again, while they've receded into the ground) and up, as nine Type 7 enemies and two more Type 14 enemies hover (and walk) down towards you from the top of the screen while shooting flames at (and extending their heads towards) you; once you've fired a shot at each of these to kill them, they will leave eleven more ghosts behind. Once you've beamed them all up, you'll come to two more Type 16 enemies who are spitting flames at you from their positions on a third wall - and once you have fired enough shots at both of them to kill them you will have to walk to the left and up over two more angry-looking spikes (once again, while they have receded into the ground) as a group of five Type 17 enemies comes flying down towards you from the top of the screen. Once you've fired enough shots at both of these to kill them (they change colour from red to peach, when they are close to defeat) for 1000 points apiece they shall leave five more ghosts behind; once you've beamed them all up, you will have to continue walking up as you come to a sixth Type 16 enemy who is spitting flames at you from his position on a fourth wall. Once you've fired enough shots at him, to kill him, you must walk to the right and upwards as a fourth Type 14 enemy comes walking down towards you from the top of the screen while extending his head towards you - and once you've fired enough shots at him to kill him, he will leave a thirty-ninth ghost behind. Once you have beamed him up, you will have to continue walking up, as you come to a seventh Type 16 enemy who's spitting flames at you from his position on a fifth wall; once you've fired enough shots at him to kill him, you'll have to walk to the right and up as you come to an eighth Type 16 enemy who is spitting flames at you from his position on a sixth wall - and once you have fired enough shots at him to kill him, you shall have to walk back to the left and up over two more angry-looking spikes (yet again, while they have receded into the ground), then fire enough shots at a shield to destroy it (like the three vases from earlier).
You'll then have to continue walking up as you come to two Type 3 boss enemies, and the game's "boss" theme starts to be heard from the Yamaha YM-2203 and YM-3812; the Type 3 boss enemies attack by spitting projectiles (and Type 18 enemies, which are worth 200 extra points and an extra ghost apiece) at the Ghostbusters while bringing their heads down on them (assuming they'd moved out of the way in time), and once you have fired enough shots at both of them to kill them for 500 points apiece they'll explode into eight red atoms (which can, again, still kill the Ghostbusters if they strike them). Once all sixteen atoms have flown off the sides of the screen, a key will appear in front of the door - and once you have collected it, the door will explode. Once all three Ghostbusters have walked through the hole in the wall where the door had been, the text "STAGE CLEARED!!" will appear on the screen for a fourth time; the "Ghost Storage" theme shall then start to get heard from the Yamaha YM-2203 and YM-3812 for a fourth occasion as all three Ghostbusters walk up to it and deposit their beamed-up ghosts into it. Once they've done so they will proceed to the fifth stage.