Shortly after the first stage begin, Stranglers will approach you, first from the right and then from the left. Eliminate them as quickly as you can and walk forward. Once you reach the ice cream shop, you should see a pair of nun-chucks on the ground. Around the same time, the first Red Mohawk should approach you. Try to grab the nun-chucks before the Red Mohawk attacks you, but don't risk your life to get them. Eventually, a second Red Mohawk will approach you from the left, and you should have more than enough time to grab the nun-chucks. Use them to take out any enemies who get close to you.
Stranglers will continue to appear, and eventually the first Dirty Jack will approach you from the right. Stay out of his stab range and use the nun-chucks or kicks to defeat him as quickly as possible. It is likely that another Red Mohawk will join the fight from the left. By the time you reach the music shop, another Dirty Jack may attack you from the right.
When you are by the doors for the club known as the Pipi Room, Stranglers will pour out from the doorway. Another Dirty Jack may join them from the left. As you proceed forward and pass the second door, a Hit Man Joe will exit the building and attempt to shoot you from behind. Be sure to duck underneath his bullet and then carefully walk backwards if you wish to attack him. Alternatively, you can ignore him and proceed to the right. It's a short distance past one other closed storefront before you reach the boss.
Boss: Axe[edit]
Also known as Raging Bison. He stands back, leaning against the van that Madonna is being held in, and lets a Crow Bar do the fighting for him. A second Crow Bar will appear behind you. However, you only have to focus your efforts on the one between you and Ace. Take that Crow Bar out as quickly as possible, and the second one will run away, leaving you to fight the boss.
Axe is strong and can knock you around a bit, but he's also very slow, and can't properly defend himself against a constant stream of attacks. It is quite possible to simply move in close to him, and tap the kick button as quickly as possible. Every attempt he makes to attack you will be interrupted by one of your kicks. He can block those kicks for a period of time, during which he will gain a little bit of health back, but he will eventually try to attack you again, and get struck by your kicks. Once you knock him out, the van carrying Madonna will drive off to the junkyard.