As soon as you enter you get a new quest: Find The Mutants.
Receive the Quest[edit]
Head North and talk to Harold. Ask him about his missing parts and you'll get a quest: Find Missing Pieces. Head out after talking with Harold to go see Hieronymus the Lost City trader. Talk to him, then leave. Come back right away and talk with him to enter the gladiator games. After talking with Giese, he'll ask you to find him junk to turn into useful stuff. So you get yet another quest: Find Old Junk. When you're done looking around town, head out to the NE to enter the bridge east.
Bridge[edit]
After you enter start by taking the NE route around this part. Follow an old broken down bridge. Look for a tiny passage to the north, follow it and jump across some sewer pipes to come out on the east. Head in that direction until you get to a pipe to the side of a truck. Jump from pipe to pipe until you are across. Soon you'll see a red car. Take the ghoul sitting on top out then continue on along the pipes.
Use the showing sewer pipes to cross the bridge. Get all the items here and then use the save module. Head west, and take your time when you are moving along. Finally you'll be stopped by a large fence. Move south and jump some pipes. Head east, save if you need to, then jump the big gap in the bridge. Move from pipe to pipe, inch by inch. Finally you'll reach the other side. Now head back to the south side of the bridge. Finally head into the docks.
Docks[edit]
Upon entering the docks you'll need to slay a few ghouls. Go ahead and do that, then head down the SE side of the docks. Save your game when you get to the SE portion of the map, then search the south side for a little treasure and some grenades. Start heading up the SW side of docks now. You'll need to break some boxes open to get through. After that, loop around some unbreakable boxes and head north along the railroad tracks. Partway along the tracks to the east is a save module if you feel like saving again. Otherwise stay on track, and keep heading to the north. advertisement
Break a few more boxes and continue on. A little ways down you'll beat up a ghoul to get a Rotten Arm for Harold. When you are unable to go north any longer head south and open a freezer that contains ammo and a weapon. Now move through the toxic sludge. You're going to want to stay as far to the north as possible, then start heading west. Soon after, you'll run into a few ghouls with homemade laser pistols. Just be careful not to get too close. Pick them off and continue west. Head through a couple red doors, grab some goodies out of the freezer to the right, then move on. This time we're headed SE.
Save on the console to the west before going on. Then move out. You'll need to jump on boxes to avoid the toxins. Continue on your path. When you get to the edge of the toxins, some ghouls will emerge. Put them down fast and use as many stimpaks as necessary. Move into the warehouse building to kill some ghouls torturing humans.
Move out the NW door. Jump across some more toxins, then save up in the corner. Search the area for caps. After doing all that, head South. Then go east to mop up some more ghouls, and after that's done head west. Take a small alley to your right to the end, collect some weapons, and a key item; some Junk. Then make your way back, opening up all the freezers along the way. Grab yourself some stimpaks, and ammo in the NW before heading south to save your game and head out onto the Docks warehouse district.
Docks Warehouse District[edit]
Head west as soon as you enter the new area. Open up the car trunk for some caps. Go north, then east. Blow up the box and grab the ammo. Then grab a few frag grenades behind the barricade. Then it's west and north to find a box with more Junk in it. Head west and save then continue on. After awhile, turn south and move all the way down. Kill the ghouls here and run down the alleyway to score some item and caps. Head back out and up to the north. Jump the barrier and continue on until you see a door to the east that you can enter. Enter it and massacre every ghoul in it. To get the ghouls to come out of the southern room just stand outside and listen to them talk for a bit.
Head out of the house and to the east. Then turn a sharp turn north and keep on running until you hit a save module. Save your game and go north again. This time, stop when you see a building to the east that you can enter. This is a church. Enter and kill all the ghouls you come across. Head toward the north end of the temple and pull the lever to open the door. Head out and to the east, and follow that alleyway to the end. There you will find a Rotten Toe for your friend Harold. After that, head out of the alley and to the west to save and enter the holding pens.
Church[edit]
Speak to Salieri upon entering. Tell him he looks familiar and you'll get a get a new quest: Deliver Package. You can also do the gladiator trials here to earn some mad cash. After that do some trading and stock up on stimpaks. After trading and getting some of that good stuff, head on over to the east.
The objective of each of these little sections is to find yourself two keys. The first one is a Gate Key. This opens a gate so you can access the next "area". The second key is the Jail Key. This is so you can rescue the human prisoners being held there. So in the first area kill all the ghouls. There should be two ghouls with the keys. Open the cages and use the action button by the humans to let them out. Then after everyone is free or dead, use the gate key you found to open the gate to the next area like this. Do the exact same thing in this area as you just did. Before opening the gate in this area though, head to the east to find the third piece of Junk. You are now going to want to head back to the Main Square of Lost.
Main Square[edit]
To do this, backtrack to the main bridge. The main bridge doors are located in the warehouse district-- you should have passed them on your way here. So head back and visit Hieronymus. He will thank you and reward you. Now visit Giese. All he'll need to make you a kick-ass weapon is some caps and those three pieces of junk you collected. Hand them over and he'll make you the Super Sledge. Head back to the holding pens to finish them up.
Open the gate and save your game once you are back. Then it's just a matter of fighting your way north. Wait for some ghouls to open the gate on that side. Then you can enter the Torture Chamber. Good luck.
Welcome to The Church Of The Lost. Population: one crazy ass ghoul and a brother paladin. Speak with your brotherhood paladin. He'll tell you all about the ghoul named Blake and his plans. He says to go slay Blake for the key to his chains. So as soon as you stop talking with Rhombus (your brotherhood paladin), Blake cuts in and you start chatting with him. Well, one thing leads to another and you have to fight him. So get ready.
Boss Battle: Blake, Cult Leader[edit]
This boss battle isn't that difficult if you have all the newest armor and weapons. If you don't, go make some cash in the gladiator battles. Just take him down with your newly acquired super sledge. It shouldn't be too long before he hits the ground. Or, you can shoot at him from afar avoiding the puddles of toxins. Whichever suits you better.
After you kill him, you get the key to the chains. Free Rhombus and he'll tell you about the key to the vault he hid. Follow him out of the church. The object now is to just follow him and protect him best you can from ghouls. Finally you'll get to a truck and a few kamikaze ghouls will run and fatally injure Rhombus. He'll give you the Laboratory Keycard to the vault and tell you to search the bridge for someone who might know something about it.
Head back to the bridge, killing some more ghouls along the way. Watch out especially for Kamikaze ghouls. They will throw themselves at you so shoot them from a distance. When you talk to Giese he'll tell you all about the Vaults. You'll also get a quest out of it: Find Secret Vault . Well what are you waiting for? Head down to the VT Warehouse.
Save the Ghouls[edit]
When you come to the door, you'll find some mutants beating the crap out of some ghouls. So give the ghouls a hand and kill the mutants. One of them drops an important item; the VT Warehouse Key. Use it to enter the warehouse.
Upon entering the warehouse, save your game. After saving, get ready for a mad killing spree, because these ghouls and mutants appear like they were comin' out of a portal in Gauntlet . Head to the west first to circle around and get a weapon or two and some armor. After that you just want to head counter-clockwise around this big donut of an area killing everything you see. The best guns for this level are the Dual-SMGs. Equip them if you have them, otherwise your strongest melee weapon will work, too. When you finally loop all the way around, you'll want to head down the stairs, into the VT Basement.
Kill the mutant rapping on the generator. Make your way around the only way to go. But beware of the mines. Use the cockroaches in this area to help you blow them up. Otherwise if you have a huge stash of home-made bombs, you could detonate some by throwing those. Finally you'll reach a save point.
Generator[edit]
The next part is hard because it involves mines and mutants. Take your time and head up towards the NW to get a new weapon. Then head back down to head through the door to the north. Head around the bend being very cautious of mines. Follow the only path you can take until you can go through a door to the west. Take that and clear out all the enemies. Then collect whatever is left and move back out into the hallway. Save a little ways up the path at the save module. Soon your path will split into two directions. You'll want to move east. Fight your way through countless mutants and giant roaches until you come to a generator. Turn it on to make the lights go on. More importantly, the elevator will work again.
Head back all the way to the west to do some treasure finding and some shopping at a vending machine. When you've finished doing what you need to on the floor head back to the east again and then to the north to enter the Sub-Basement.
Boss Battle: Robot Turrets[edit]
The two best weapons to use on these guys are the laser rifles, and the rocket launchers. After those any of the others will chip off a fair amount. Start on the west and work your way around. You'll need a lot of stimpaks as well. You did it, you found the vault.