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- This guide is for the 1987 arcade version. For 2007 remake, see Alien Syndrome (2007).
Alien Syndrome is a run and gun arcade game developed by Sega in 1987. An unlicensed NES port was published by Tengen.
Two players control two soldiers named Ricky and Mary, who must fight their way through large eight-way scrolling levels rescuing their comrades who are being held by aliens. After they have rescued a certain number of hostages the exit opens and they can pass through it in order to fight the end-of-level guardian. If this monstrosity is defeated, they move onto the next stage. As well as two player simultaneous gameplay, Alien Syndrome features pick-ups which assist the player including better weapons and maps of the current level.