Hamtaro: Ham-Ham Heartbreak (とっとこハム太郎3 ラブラブ大冒険でちゅ Tottoko Hamutaro 3: Love Love Daibōken Dechu?) is a Nintendo video game for Game Boy Advance and the sequel to Tottoko Hamutaro: Tomodachi Daisakusen Dechu (Japan only) and Hamtaro: Ham-Hams Unite!. Therefore, it is the second Hamtaro game released in America and Europe, but the third one in Japan. It was released in Japan on May 3, 2002, in the USA on April 8, 2003 and in Europe on June 27, 2004.
After Ham-Ham Heartbreak, only one more Hamtaro adventure game was released: Hamtaro: Rainbow Rescue.
Like its predecessors, Ham-Ham Heartbreak is an adventure game. Set in the world of the Hamtaro books and anime, the player controls the hamster (Ham-Ham, as the hamsters tend to call themselves) Hamtaro. Ham-Ham Heartbreak expands on the gameplay of the earlier titles by adding Bijou, Hamtaro's girlfriend, as partner. Together, they have to save the other ham-hams from an evil hamster with a hatred for any kind of relation.