There are four bosses in the game. The first three bosses return together in the fifth stage.
Gizmo has two phases. The first phase consists of long-range attacks while flying and holograms to confuse you. His second phase includes color-coordinated shields to protect him while throwing bombs.
Jinx can send out curses in the form of energy bolts, which will reverse the player's controlling directions upon contact. She can also absorb health points from you into her own. By firing an energy beam upward, she can cause several ceiling plates to fall randomly.
Mammoth attacks by punching the ground to send shockwaves, followed by hurling the boxes behind him. With Mammoth, there will be strong wind trying to push you off the stage. He can only be hurt when stunned by his own attack.
Brother Blood is the final boss of the game. His attacks include psychic shockwaves, dashing attacks, energy sword, and paralyzing portals. The shockwaves will leave behind hazardous embers randomly, while the portals will stun your movement temporarily, enabling him to teleport to and slash at the player. In melee combat, he does not use his sword much; instead, he usually dashes toward you.