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Button Function
Neutral dpad Moving around.
Start button Pause the game to save your progress.
A button Advance through dialog, examine, talk, select evidence, check evidence.
B button Cancel, fast-forward through dialog, running.
X button Present evidence.
Y button Activates the microphone.
L button Pressing during confrontation.
R button Opens up the organizer.

Note that the Stylus button can be used to play the game entirely, but it's not really necessary for anything.