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Use the following safe location guide along with the safe location maps to find all 100 safes.
Little Italy
View entire Little Italy safe location map
| No. | Location | Floor | Area of Building |
| 1.) | Saint Martin Hotel | 3rd | SE |
| 2.) | Bella Siciliana | 1st | NW |
| 3.) | Sicilian Imports Inc. | 2nd | SW |
| 4.) | Bowery Hotel | 4th | NE |
| 5.) | Chinaware Warehouse | 1st | NE |
| 6.) | Dr. Harvey's Clinic | 1st | NW |
| 7.) | Dr. Valachi (Clinic) | 1st | SE |
| 8.) | Harry's Bar | 1st | SW |
| 9.) | Primola | 1st | NW |
| 10.) | Arezzo Seafood | 1st | SE |
| 11.) | Boolie's Bakery | Basement | NE |
| 12.) | Emilio's Butcher Shop | 2nd | SW |
| 13.) | DeMantagnas | 1st | SW |
| 14.) | Global Trading Co. | 2nd | SE |
| 15.) | Smoke Signals | 2nd | SE |
| 16.) | Trapani's Bakery | Basement | SE |
| 17.) | Sammy's | 1st | NW |
| 18.) | Italia Hauling Co. | 2nd | SE of N building |
| 19.) | Hotel Alioto | 3rd | SE |
| 20.) | Va Va Voom Room | 1st | SE |
| 21.) | The Continental | 1st | SW |
| 22.) | Verona Warehouse | 1st | SE |
| 23.) | Lipari Warehouse | 2nd | NW of N building |
Brooklyn
| No. | Location | Floor | Area of Building |
| 24.) | Cafe Vitales | 2nd | NE |
| 25.) | The Ambassador | 2nd | NE |
| 26.) | Midnight Rosie's | 2nd | W |
| 27.) | The Full Moon | Basement | SE |
| 28.) | Global Trading Co. | 2nd | S |
| 29.) | Wright Wronsky's | 2nd | SW |
| 30.) | Michelangelo Salera | 1st | NE |
| 31.) | Liberto's | Basement | E |
| 32.) | S. Elia Warehouse | 1st | NW |
| 33.) | Valentino's | 1st | NE |
| 34.) | St. Sebastian Hotel | 4th | NE |
| 35.) | Tattaglia Hub | 1st | NW |
| 36.) | Tattaglia Compound | 2nd | S of S building |
| 37.) | Dr. Marshall's Clinic | 1st | NW |
| 38.) | Sicilian Goods | 2nd | SE |
Midtown
View entire Midtown safe location map
| No. | Location | Floor | Area of Building |
| 39.) | St. Alban's Hotel | 3rd | NW |
| 40.) | Orchid Inc. | 1st | SW |
| 41.) | Dr. Alexander Noel (Clinic) | 1st | NW |
| 42.) | Flowers of Scotland | 1st | NE |
| 43.) | Madame Polly's | 2nd | SE |
| 44.) | J. Sizzle's Steakhouse | 1st | N |
| 45.) | The Luna Bar | Basement | SW |
| 46.) | Isao Kimota | 1st | NW |
| 47.) | Chateau Toledo | 1st | SE |
| 48.) | Palermo Warehouse | 1st | SW* |
| 49.) | Barzini Hub | 2nd | SW of S building |
| 50.) | The Peak | 3rd | NE |
*go into building, jump through window ahead, go to the right and into door you find
| 51.) | Hotel Madison | 4th | SW |
| 52.) | The Carnegie Club | 4th | SW |
| 53.) | Barzini Compound | 2nd | E of W building |
| 54.) | West Side Willy's | 1st | NE |
| 55.) | Lumpy's Bar | 1st | S |
| 56.) | Savannah Hotel | 3rd | E |
| 57.) | The Colonial Club | 1st | SE |
| 58.) | Raphael's | 1st | NE |
| 59.) | Hawk's Steakhouse | 2nd | NW |
| 60.) | Palladio Willow | 1st | SW |
Hell's Kitchen
View entire Hell's Kitchen safe location map
| No. | Location | Floor | Area of Building |
| 61.) | Mrs. Spillane's | 4th | SE |
| 62.) | The Tunnel Club | Basement | SE |
| 63.) | Scotty's Biscotti | Basement | S |
| 64.) | Caruso! | Basement | S |
| 65.) | Dr. O'Riains (Eastern Clinic) | 1st | SW |
| 66.) | Milk Co. Warehouse | 1st | SW of N building |
| 67.) | Poppy's - Westside | Basement | SE |
| 68.) | Hell's Kitchen Clinic | 1st | SW |
| 69.) | Casey Quinn's | 2nd | SW |
| 70.) | Holden Holdings | 2nd | S |
| 71.) | Tyler's Top Cuts | 1st | NW |
| 72.) | The Elegante | 3rd | SE |
| 73.) | West Side Philly's | 1st | SE |
| 74.) | Arezzo Seafood | 1st | NE |
| 75.) | Doc Thody's Dahlias | 1st | SE |
| 76.) | The Red Fox | 1st | N |
| 77.) | Orchid Inc. | 1st | SE |
| 78.) | Providence Hotel | 4th | SE |
| 79.) | M. Powers & Sons | Basement | NW |
| 80.) | Cuneo Compound | 2nd | SE of E building |
| 81.) | Dale Mangano's | 1st | SW |
| 82.) | Cuneo Hub | 1st | NE |
| 83.) | The Colonial Tavern | 1st | NE |
| 84.) | After Hours | 1st | SE |
New Jersey
| No. | Location | Floor | Area of Building |
| 85.) | Santo | 1st | S |
| 86.) | The George Hotel | 3rd | SW |
| 87.) | Waterside Warehouse | 1st | N |
| 88.) | The Crane Club | 1st | SE |
| 89.) | Velveteen's | Basement | SW |
| 90.) | Joe Foley's | Basement | Middle |
| 91.) | Fabio Satriani and Sons | 2nd | SE |
| 92.) | Joey's Baked Goods | Basement | N |
| 93.) | Arnold's Famous 47 | 2nd | NW |
| 94.) | B. Fidanque, MD (Clinic) | 1st | SE |
| 95.) | Stracci Compound | 2nd | NE of S building |
| 96.) | Boris Amchini | 1st | SE |
| 97.) | The Highway Hotel | 3rd | SW |
| 98.) | Sicilian Goods | 2nd | N |
| 99.) | Stracci Hub | 1st | SE |
| 100.) | Johnny Congers | 1st | SE |