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Plasmids
Combat Tonics
- Armored Shell - Can be purchased at the very first Gatherer's Garden machine.
- Armored Shell 2 - Awarded for saving Little Sisters / Second Tonic Reward
- Damage Research - Hephaestus / Across from the EMP bomb on a table
- Damage Research 2 - Point Prometheus / Upstairs / Center of Library on desk
- Electric Flesh - Fort Frolic / The Projector Room in the Theater / On bookshelf
- Electric Flesh 2 - Olympic Heights / Fontaine's apartment / In the office on the desk
- Frozen Field - Fort Frolic / Awarded for killing the Cohen victim in the freezer
- Frozen Field 2 - Hephaestus - Room off entrance to Ryan's office - on desk
- Human Inferno - Arcadia Gatherer's Garden machine / 20 Adam
- Human Inferno 2 - Purchase at Gatherer's Garden machine in Point Prometheus
- Photographer's Eye - Purchase at Gatherer's Garden machine
- Photographer's Eye 2 - Research the Rosie Big Daddy.
- Static Discarge - Medicial Pavilion / In the hallway after fighting Steinman.
- Static Discharge 2 - Research Leadhead splicers
- Wrench Jockey - Medical Pavilion / Seen from a window. In a back room, reached by airshaft.
- Wrench Jockey 2 - Research Bouncer Big Daddy
- Wrench Lurker - Neptune's Bounty / Sitting on the ledge near the plasmid machine.
- Wrench Lurker 2 - Available at the Point Prometheus Gatherer's Garden
Engineering Tonics
- Alarm Expert - Fort Frolic / Theater / Top Left balcony sitting on the ledge
- Alarm Expert 2 - Point Prometheus / Optimized Eugenics / on filing cabinet
- Clever Inventor - Suchong's Apartment / Beside the tape recorder
- Focused Hacker - Neptune's Bounty / In the area right before fighting Peach Wilkins.
- Focused Hacker 2 - Apollo Square / In the Slums near Bathysphere / Atlas's Headquarters
- Hacking Expert - Arcadia / Sitting on the first desk in Langford Labs
- Hacking Expert 2 - Available at the Point Prometheus Gatherer's Garden
- Prolific Inventor - Awarded for saving Little Sisters / Last Tonic reward
- Safecracker - Awarded for saving Little Sisters / First Tonic reward
- Safecracker 2 - Point Prometheus / Little Wonders / In back room with Gene Bank
- Security Expert - Medical Pavilion / On a small chest in the morgue.
- Security Expert 2 - Research the flying Security Bot
- Shorten Alarms - Neptune's bounty / Near "Saw Masha Today" recording or buy it at a Gatherer's Garden machine in Arcadia.
- Shorten Alarms 2 - Hephaestus / On the floor right before setting off the EMP.
- Speedy Hacker - Medical Pavilion / On the desk in the dentist's lab.
- Speedy Hacker 2 -Available at the Point Prometheus Gatherer's Garden
Physical Tonics
- BloodLust - U-Invent machine / Inventable after Arcadia
- Booze Hound - U-Invent MAchine / Inventable after Arcadia
- Eve Link - Sold at Gatherer's Garden machines
- Eve Link 2 - Farmer's Market / On the ground near U-Invent & vending machines.
- Extra Nutrition - Sold at Gatherer's Garden machines.
- Extra Nutrition 2 - Storage Basement of the mall area in Fort Frolic. Covered by metal grate if Cohen dies. Also purchasable.
- Extra Nutrition 3 - Research Spider splicers
- Hacker's Delight - Medical Pavilion / Eternal Flame / Cremate the body near the camera.
- Hacker's Delight 2 - U-Invent machine / Inventable after Arcadia
- Hacker's Delight 3 - Point Prometheus / Same room as the Big Daddy Helmet.
- Medical Expert - Neptune's Bounty / In the center of the muddy section of the Lower Wharf.
- Medical Expert 2 - Fort Frolic / Awarded by an alive Cohen or bought in Hephestus
- Medical Expert 3 - Apollo Square / Second floor / Opposite end from 2nd dose of lot 192.
- Natural Camoflouge - Research the Houdini Splicers
- Scrounger - Research Leadhead splicers
- Security Evasion - Arcadia / In the center of a group of splicers, near an Invent machine.
- Security Evasion 2 - Hephaestus / Heat Monitoring / Across from electricuted ghost scene, sitting on desk
- Sportboost - Research Thuggish splicers
- Sportboost 2 - Research Thuggish Splicers