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The Cerulean Cave is filled with the strongest wild Pokémon. It's quite an interesting place to navigate, because it feels like you'll never reach where you want to go. After going through mazes several times, you'll find Mewtwo between two rocks.
Mewtwo is a level 70 Psychic Pokémon and considered to be the strongest Pokémon in the original games. This Mewtwo knows the moves Psychic, Swift, Recover, and Safeguard. Use the Master Ball (hopefully that wasn't used already). Mewtwo is nearly impossible to catch without the Master Ball, but that doesn't mean it is impossible.
- Try to paralyze Mewtwo with Pikachu or a fast Dragonite/Dragonair before Mewtwo uses Safeguard, then weaken Mewtwo down to red health.
- Mewtwo will Recover when it's weakened.
- When you finally manage to get Mewtwo's health down to red, throw a Master, Ultra or Great Balls.
- After a lot of turns have past, start using the timer balls.
After catching Mewtwo, you should be proud to be the owner of the most powerful Pokémon in the original 151!