Reploid/Human
- Main Weapon: Buster Shot
This is Grey's/Ashe's normal form. In this form, you can crouch, crawl, and float along the surface of water. However, you can't dash or climb walls. This form comes with a basic buster gun that cannot be charged. Grey's gun can have three bullets on-screen at a time, while Ashe's can only have two.
Model A
- Main Weapon: Buster Shot
- Sub Weapon: Homing Shot
This form has a chargeable buster gun. Grey's gun can have three bullets on-screen at a time, and can fire charged shots similar to those of Model X in the first ZX game. Ashe's gun can only have two bullets on-screen at a time, but her fully charged shot is a long, thin "Reflect Laser" that rebounds off walls, much like the Gemini Laser from Mega Man 3.
The sub weapon is the Homing Shot. Hold the sub weapon button and the gun projects a conical field in front of you. Any enemy that enters this field will be targeted, and will remain targeted even if they move outside of the field. After targeting some enemies, release the button to fire. Grey will fire a bunch of shots that will home in on each targeted enemy, while Ashe will fire a single shot that hits every targeted enemy, one at a time. This uses weapon energy.
This form also has the Giga Crush attack. Hold the Giga Crush button and a cube appears around you and expands. When it reaches full size, release the button to fire a barrage of shots that hit every enemy on the screen. This uses all of your weapon energy, and can thus only be used when your weapon energy gauge is full.
Other Mega Men
Aile/Vent
- Main Weapon: ZX Saber
- Sub Weapon: ZX Buster
As Grey you'll copy Aile, and as Ashe you'll copy Vent. Either way, you use Model ZX in this form, which plays very similarly to the first ZX game. You can perform a triple slash with the ZX Saber by pressing the button three times quickly, a rolling slash by pressing 
+ Main Weapon in midair, and a charged slash by holding down the Main Weapon button and releasing it. The charged slash uses weapon energy. Also, by holding 
just after performing a midair slash, you can keep your ZX Saber held out until you hit the ground, so it can damage enemies below you.
There's also a new technique you can use with this form. As Aile (Grey), press + Main Weapon in midair to perform "Fission", a straight downward stab that releases energy balls a short distance around you when it hits the ground. As Vent (Ashe), press + Main Weapon on the ground to perform "Rising Fang", a rising uppercut that fires an energy wave forwards.
You also get the ZX Buster, which operates the same way as in the first ZX game, except that its fully-charged shots now use weapon energy.
Aeolus
- Main Weapon: Short Saber
- Sub Weapon: Long Saber
As the Model H Mega Man, Aeolus plays very similarly to Model HX from the first ZX game. He wields two sabers; press Main Weapon, Sub Weapon, Main Weapon in quick succession to perform a triple slash, and the third slash fires an energy wave a short distance in front of you. Also, charge up either saber and release to fire two Plasma Cyclones. Grey fires them both forwards, one diagonally up, the other diagonally down, while Ashe fires one straight forwards and one straight backwards. These cyclones are Lightning elements, and they use weapon energy.
This form also allows you to air-dash sideways by pressing the Dash button in midair, or upwards by pressing + Dash in midair. You can also hover by either pressing or holding down the Jump button in midair (you can toggle this from the Options Screen).
This form also has the Enemy Analyzing feature which displays enemies' life meters and bosses' weak points on the lower screen.