This game will get you through this superhero action RPG game. The things you do could either get you through the game or could get you stuck. Also you'll encounter lots and lots of secrets throughout the game and bosses which requires a unique strategy to defeat them.
Also, you should upgrade your superhero stats to avoid certain defeat. Most importantly on defense. Speaking of which, if you want full control of what superpowers your going to use, turn the auto spend off but if you're interested in just playing the game, leave the auto spend on.
Be wary that certain bosses can't be defeated by normal means. Look for moments like button sequences or Wii motion sequences, with or without a weapon, or things that you need to do before you take down the boss.
Lastly, if change into a more different team, your interaction can differ depending on which person you encounter is part of your universe. Like Wolverine's encounter with Dum Dum Dugan on the Omega Base.