Talk to the man in the Venus Bar, drive to the hotel in a car with good armour and take out all those you can in the car. If you keep your distance, you can take out quite a few without any hassle, but when you get close don't dawdle, as there is a time limit. You have to storm the compound, and if you have blind rage it's best to use it when you're going up the stairs. The stairs can be a problem spot, as you can be shot at from all angles, so take care. Naturally, once you get on the top floor don't shoot the girl. Heal yourself with the medical pack if needed and lead the girl back to your car. There shouldn't be anybody left alive downstairs, but keep your eye on the radar. When you're driving her back, watch out for gangs in cars but they shouldn't be too much of a hassle.