This double boss battle starts with Peter Parker fighting Silver Sable. One of the most annoying parts of this battle is her thugs with tommy guns. Prepare to use the dodge button a lot because you will need to dodge lots of bullets, ninja stars and tranquillizers. Sable will start off flipping around a lot this is just to put some distance between you both so she can over use her ninja stars. When the spider sense goes off, run towards her while dodging then starting a combo. It may works best if you keep the combos simple (e.g all punches or kicks) because she seems to move less that way. Whenever a guard with a gun shows up, take him out quickly. The thugs with guns take off more damage then the ninja stars do. After a while you should manage to get in the final blow and move on to Venom.
Now its Spiderman vs Venom for second time. The first thing to do is to switch to your adrenaline rush special move. Venom will try and grab you with his long tentacle to feed on you whenever you run toward him, so get ready to dodge when you see that spider sense. It is recommended to run at him and dodge because it sets you up for instant combos. He will eventually feed on you (probably more then once) but don't worry. Once you get your special full, just punch and kick him until you win. Then sit back and watch the cinematic.