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After completing the Search for Cain and returning Charsi's Tools of the Trade from the Barracks of the Monastery, you can talk to Deckard Cain to activate the sixth, final and thus far only mandatory quest of the first Act.

Deckard Cain
It is certain that we face the demon queen, Andariel, who has corrupted the Rogue Sisterhood and defiled their ancestral Monastery. This does not bode well for us, my friend.

Ancient Horadric texts record that Andariel and the other Lesser Evils once ovethrew the three Prime Evils - Diablo, Mephisto and Baal - banishing them from Hell to our world. Here, they caused mankind untold anguish and suffering before they were finally bound within the Soulstones.

Andariel's presence here could mean that the forces of Hell are once again aligned behind Diablo and his Brothers. If this is true, then I fear for us all.

You must kill her before the Monastery becomes a permanent outpost of Hell and the way east lost forever.
DII Icon Sisters to the Slaughter.png Sisters to the Slaughter
Find Andariel's Lair in the depths of the Monastery Catacombs.

If you talk to anyone before leaving the camp:

Akara Warriv Gheed
Andariel has desecrated all we hold dear. She must not be permitted to serve Diablo.

Destroy her! Her corruption of our Order must be undone!
The mapmakers tell us the shortest distance between two points is a straight line.

Our way east is a line that runs through Andariel's stronghold, the Monastery.
You're going after Andariel?

... One of my wagon wheels is in need of repair. I'll be under the wagon, if I'm needed.
Kashya Charsi
I can imagine a thousand different ways to kill Andariel. You need only choose one. Send Andariel back to the Hell she came from!

Deckard Cain also has some new gossip:

Sisters to the Slaughter Gossip
Diablo is heading east for some foul purpose. And the only passage east is through the Monastery gate. Obviously, Diablo summoned Andariel to block any pursuit.

For her part Andariel hopes to win Diablo's favor... the lesser demons are always vying for positions of power within the unholy hierarchy!
Long ago, the Soulstones were given to the Horadrim by the Archangel Tyrael. They were used to bind the three Prime Evils. I now know that even these holy artifacts were no match for Diablo's power.

I hope that his two brothers are more securely held... but I fear the worst.

At this stage you should have made it at least as far as the Barracks inside the Monastery, where you'll find the stairs down to the first level of the Jail. You now need to travel through the three levels of the Jail to the Inner Cloister outside the Cathedral, within which you'll find the entrance to the Catacombs.

Jail Level 1[edit]

The first level is randomly populated by three of the following five monster types: Bone Archers, fiery Bone Mages, Dark Ones, Death Clan Goatmen and Wraiths. You may also find Gargoyle Traps, and non-random Champion and Unique monsters in addition to those randomly generated.

You're most likely to find the most direct route to a waypoint by traveling left after entry, and continue doing so for the most direct route to the second level.

Jail Level 2[edit]

The second level is similarly populated to the first. If you continue traveling left after entry then you're likely to encounter Pitspawn Fouldog before you find the stairs down to the third level; if you wish to avoid this then travel right after entry.

Pitspawn Fouldog[edit]

Super Unique Tainted (Cursed Cold Enchanted)

Pitspawn Fouldog can be found in a cul-de-sac. Like Griswold, it can curse you with Amplify Damage, and the damaging lightning balls it and its minions spit can also slow you with cold. This can be a difficult and dangerous fight, particularly in Normal, even if you Cannot be Frozen, and before it explodes in a cold nova upon death.

Jail Level 3[edit]

The third and final level is similarly populated to the previous two, except electric Bone Mages replace fiery ones. You're most likely to find the most direct route to the stairs up to the Inner Cloister by traveling left after entry.

Inner Cloister[edit]

The stairs up from the third level of the Jail are in the north corner of the Inner Cloister. It always has the same layout, with a waypoint in the middle of the cloister through the doors to the south. Although it's supposed to be populated by Black Archers, electric Bone Mages and Dark Ones, it's so small that you might not see all or many of them.

The doors to the Cathedral are in the middle of the cloister's northeast wall.

Cathedral[edit]

Like the Inner Cloister, the Cathedral always has the same layout as well. The altar is to the northeast, at the junction of its cross-like structure, with long galleries to either side of its body and a small room to the left of its head; the stairs down to the Catacombs Level 1 are in the northeast wall of its right arm, so the most direct route is through the gallery to the right of the entrance and the door at its northeastern end to the right arm, which allows you to avoid Bone Ash if you wish.

Otherwise, the Cathedral is populated by Dark Shamans and Dark Ones, Tainted and Wraiths.

Bone Ash[edit]

Super Unique Skeleton Mage (Magic Resistant Extra Strong Cold Enchanted)

Bone Ash stands before the altar at the heart of the cathedral. Due to its Unique bonuses it's Immune to Cold, even in Normal, and its poison bolts can slow with cold. Otherwise, it isn't particularly dangerous.

Catacombs Level 1[edit]

If you haven't already activated this quest by talking to Deckard Cain, then entering the Catacombs does so:

DII Icon Sisters to the Slaughter.png Sisters to the Slaughter
Find Andariel's Lair in the depths of the Monastery Catacombs.

If you return to camp to talk to anyone before completing this quest:

Akara Deckard Cain
You have done much to help us, but I sense that this has only fueled Andariel's fury. She will not stop until we are all dead.

You must kill Andariel before her army can gain the upper hand.
It is clear that Andariel is acting on behalf of Diablo to prevent anyone from following him eastward. Her defeat would allow you to continue the pursuit.

Ancient lore has it that while Andariel was spawned in the Burning Hells, she is not fond of fire.
Kashya Charsi Warriv Gheed
Deckard Cain has important information about Andariel. If you are the hero that you seem to be, now is the time to prove it. May I remind you that my caravan can only go east, if the Monastery is cleansed? Have you stumbled upon that Demon Queen, yet? I hear she's quite the beauty... as far as Maidens of Anguish go, that is.

The first level is populated by Dark Shamans and Dark Ones, Rat Man and Tainted. You may also find Gargoyle Traps, and non-random Champion and Unique monsters in addition to those randomly generated.

Catacombs Level 2[edit]

The second level is similarly populated to the previous, except Arachs (Giant Spiders) replace Rat Men. You're most likely to find the most direct route to the stairs down to the third level by traveling left after entry, and continue doing so for the most direct route to the final waypoint in the Act. Create a Town Portal at the stairs so that once you've found this waypoint you can return from camp; if you find the waypoint first then travel right, to the stairs.

Catacombs Level 3[edit]

The third level is populated by Afflicted, Banished (Vampires) and Ghouls. You may also find Gargoyle Traps, and non-random Champion and Unique monsters in addition to those randomly generated.

Catacombs Level 4[edit]

DII Icon Sisters to the Slaughter.png Sisters to the Slaughter
Kill Andariel.

The fourth and final level of the Catacombs is much smaller than the previous three, and always has the same layout: the stairs down from the third level are in the northeast wall of a room on its right side, and through the closed door in the middle of its northwest wall is the reception area for the throne room, which is beyond the closed doors in the northeast wall. In the middle of the reception area is a sunken pit, filled with blood and corpses.

The level is randomly populated by Afflicted and Ghouls, with four Dark Shamans and their Dark Ones in the reception area (one in the east corner, the others along the northwest side), and another three in the throne room itself (one in its right arm at its southwestern end, another just north of its junction and the last at the northeast end of its body).

It's advisable to kill everything in the level up to the junction of the throne room (including the Dark Shaman and its Dark Ones just to its north, if possible) before advancing into its body to confront Andariel herself. It may also be advisable to create a Town Portal somewhere outside the throne room (possibly even back up the stairs in the third level), and make sure you have plenty of healing and mana potions: if your poison resistance isn't particularly high, you should also drink multiple Antidote Potions before the confrontation.

Andariel[edit]

Evil

Die, maggot!

Fear me!

Andariel promotional art. "The most powerful of the Lesser Evils, Andariel hopes to gain the Three's favor by enslaving the monastery residents and making them her army."

Andariel is a melee attacker who can also shoot poison bolts and a poison spray, both of which also inflict physical damage (so they can be blocked with a shield). She also inflicts 200% damage on any mercenary, which may not survive unless you or your pets bear the brunt of her fury (although she inflicts 400% damage on pets). If you're having trouble going toe-to-toe with her, retreat to the reception area and try using ranged attacks and skills while she chases you around the sunken pit in its midst.

Sometimes, just sometimes, it's actually useful to talk to the people in camp, and if you do so with Deckard Cain you'll learn that Andariel isn't fond of fire. She has Fire Resist -50% in all difficulties, which means fire damage of any kind is normally increased by 50% against her: if your class doesn't have any Fire Skills then there are items which add fire damage to attacks (if nothing else in Normal, you can place the highest quality Rubies you have in a weapon with sockets). Unfortunately, the fires dotted around the level only damage you, not her.

When you finally kill her, the screen shakes as she erupts in a pillar of fire with fingers of flame snaking across the floor as rubble falls from the ceiling, lethal to any nearby monsters but harmless to you and your party. She always drops two chipped gems and one of normal quality in all difficulties, and a portal back to camp opens.

DII Icon Sisters to the Slaughter.png Sisters to the Slaughter
Return to Warriv to take the Caravan East.

If you talk to anyone but Warriv upon your return:

Akara Kashya Deckard Cain
Finally, we may rejoice!

We owe you a debt we can never repay. I only hope that in time we will be able to rebuild our Order.

All our thanks go with you, my friend.
Andariel's death brings about renewed life for us all. We mourn the loss of our dear Sisters, but at least now we can get on with our lives.

I... may have misjudged you, outlander. You are a true hero and testament to the noble spirit which has inspired our Order for generations.

Fare well... my friend.
This is a great victory indeed, but many more battles await. I will accompany you on your journey, lending what assistance I can...

Remember... Diablo is still out there, seeking something in the desert. I'm afraid that this nightmare will not end until you find what it is that he seeks.
Charsi Gheed
You'll probably go east now... It was good to know you. I hope you'll come back if you ever need anything. I'm going to party like it's 999!

Talk to Warriv:

Warriv
The caravan is prepared. We may now journey eastward to Lut Gholein.

You can now go east with him, to Lut Gholein.

DII Icon Sisters to the Slaughter.png Sisters to the Slaughter
Quest completed.
DII Icon Sisters to the Slaughter.png Sisters to the Slaughter
You completed this quest in a previous game.