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| Item | Description | Location |
|---|---|---|
| Amulet Coin | Doubles earnings from Pokémon battles | Goldenrod Underground (see Radio Tower) |
| Berserk Gene | Boosts Attack but causes confusion | Cerulean City, where Mewtwo cave was |
| Black Belt | Increase power of Fighting-type attacks by 10%. | Lake of Rage (Wednesday) |
| Blackglasses | Increases the power of Dark-type attacks by 10%. | Dark Cave |
| Bright Powder | Lowers the opponent's accuracy | Traded (RBY) Legendary |
| Charcoal | Increases the power of Fire-type attacks by 10%. | Azalea Town, Ruins of Alph (Crystal) |
| Cleanse Tag | Repels wild Pokémon | Route 5 |
| Dragon Fang | No effect due to a coding error | Dragon's Den |
| Dragon Scale | Evolves Seadra during trading/Increases the power of Dragon-type moves by 10%. | Mt. Mortar |
| Everstone | Prevents a Pokémon from evolving | 2nd Place Reward for Bug Catching Contest/Professor Elm |
| Exp. Share | Receives experience from uninvolved battles | Trade Red Scale to Mr. Pokémon |
| Focus Band | Prevents a Pokémon from fainting occasionally | Fighting Dojo |
| Hard Stone | Increase power of Rock-type attacks by 10%. | Route 36 (Thursday), Wild Larvitar
(5% chance) |
| King's Rock | Evolves Poliwhirl/Slowpoke during trading/May cause flinching | Slowpoke Well |
| Leftovers | Recovers HP gradually during battle | Caught with Snorlax, Celadon City Cafe (In Trash Can) |
| Light Ball | Doubles Pikachu's Special Attack | Held by Yellow's Partner Pokémon |
| Lucky Egg | Boosts EXP. yield from battles by 150%. | Held by wild Chansey/ Blissey
(5% chance) |
| Lucky Punch | Ups critical hit ratio of Chansey | Held by Generation I Chansey |
| Magnet | Increases the power of Electric-type attacks by 10%. | Route 37 (Sunday) |
| Metal Coat | Increases the power of Steel-type attacks by 10%. | S.S. Aqua,
Held by Maggie (Magneton) In-game trade |
| Metal Powder | Raises Defense and Special Defense of Ditto | Held by Generation I Ditto |
| Miracle Seed | Increases the power of Grass-type attacks by 10%. | Man at Route 32 after beating Gym |
| Mystic Water | Increases the power of Water-type attacks by 10%. | Cherrygrove City,
Ruins of Alph (Crystal) |
| Nevermeltice | Increases the power of Ice-type attacks by 10%. | Ice Cave |
| Pink Bow | Powers up normal-type moves by 10%. | Route 29 (Tuesday) and Radio Tower |
| Poison Barb | Increases power of Poison-type attacks by 10%. | Route 32 (Friday), Wild Beedrill (50% chance) |
| Polkadot Bow | Powers up normal-type moves by 10%. | Mystery Gift/Trade a Jigglypuff from Red, Blue, or Yellow. |
| Quick Claw | Increases chance of attacking first | National Park |
| Scope Lens | Boosts critical hit ratio | Mystery Gift |
| Sharp Beak | Increases power of Flying-type attacks by 10%. | Route 40 (Monday),
Wild Fearow (5% chance) |
| Silver Powder | Increases power of Bug-type attacks by 10%. | Held by wild Butterfree |
| Smoke Ball | Escape from wild Pokémon | Goldenrod Underground (Basement),
Held by Doris (Dodrio) In-game trade (Crystal) |
| Soft Sand | Increases the power of Ground-type attacks by 10%. | Route 34 |
| Spell Tag | Increases the power of Ghost-type attacks by 10%. | Blackthorn City (Saturday) |
| Stick | Boosts critical hit ratio of Farfetch'd +2 Stages | Held by wild Farfetch'd
(5% Chance) |
| Twisted Spoon | Increases the power of Psychic-type attacks by 10%. | Held by Yellow Kadabra |
| Thick Club | Doubles the attack if held by Cubone or Marowak | Held by wild Cubone and Marowak
(5% Chance) |
| TM09-Psych Up | Normal-Type Status move that copies negative and positive stat changes. | Held by Gen. 1 Abra
(Only way to get in Gen. 2) |