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Select Key Mapping from Gameplay Options to change keyboard configuration by selecting each function and pressing a different key, or restore Default.

Movement

Function Keyboard and mouse Xbox
Move Forward  W  Up lstick
Move Backwards  S  Down lstick
Move Left  Z  Left lstick
Move Right  C  Right lstick
Pan Camera Left  A  or Mouse (edge of screen) Left rstick
Pan Camera Right  D  or Mouse (edge of screen) Right rstick
Free Look  CAPSLOCK  Click Neutral rstick
Look About Hold  CTRL  or Mouse right click
Game Menu  ESC  Start button
Select Previous (Left)  Q  LT button
Select Next (Right)  E  RT button
Run / Walk Hold  B 

Game

Function Keyboard and mouse Xbox
Pause Game  PAUSE  or  SPACE  White button
Default Action  R  or Mouse left click A button
Activate Left Action  1 
Activate Middle Action  2 
Activate Right Action  3 
Activate Friendly Power  4 
Activate Medical Item (Medpacs or Repair kits)  5 
Activate Non-medical Item (Shields or Stimulants)  6 
Activate Mine  7 
Party Select Screen  L 
Map Screen  M 
Journal Screen  J 
Abilities Screen (Skills, Powers and Feats)  K 
Options Screen  O 
Character Screen  P 
Inventory Screen  I 
Equipment Screen  U 
Cancel combat  F 
Change Leader  TAB  Black button
Solo Mode  V  Back button
Toggle Stealth  G 
Flourish Weapon(s)  X  Y button
Tool Tips Hold  T 
Quick Save  F4 
Quick Load  F5 
Previous Menu  Q 
Next Menu  E 
Clear Combat Action  Y  Y button
Cycle Actions Mouse left click Neutral dpad
Add Combat Action Mouse left click X button
Cancel  Esc  or Mouse left click (Cancel, Close) B button

Mini Games

Function Keyboard and mouse Xbox
Move Forward (Up)  W  or  ↑  or Mouse Up lstick
Move Backwards (Down)  S  or  ↓  or Mouse Down lstick
Move Left  A  or or Mouse Left lstick
Move Right  D  or or Mouse Right lstick
Mini-Game Action  SPACE  or Mouse left click A button
Pause Mini-Game  ESC  or  PAUSE  White button