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Big Smoke's Cash is a side mission and does not need to be completed for 100% completion. It starts with a call from Cesar saying that the cash is leaving Los Santos. They are using a patriot jeep and start at Grove Street; the mission ends when they get to pier 69. When you catch up to the patriot you have to ram it six times to get all six boxes of cash to fall out. Drive over each box to pick up the cash. The reward is cash from the boxes. You must do this mission before you do the Yay Ka-Boom-Boom mission.